Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1126/sciimmunol.abg5021

http://scihub22266oqcxt.onion/10.1126/sciimmunol.abg5021
suck pdf from google scholar
34376481!ä!34376481

suck abstract from ncbi


Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid34376481      Sci+Immunol 2021 ; 6 (62): ä
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients #MMPMID34376481
  • Notarbartolo S; Ranzani V; Bandera A; Gruarin P; Bevilacqua V; Putignano AR; Gobbini A; Galeota E; Manara C; Bombaci M; Pesce E; Zagato E; Favalli A; Sarnicola ML; Curti S; Crosti M; Martinovic M; Fabbris T; Marini F; Donnici L; Lorenzo M; Mancino M; Ungaro R; Lombardi A; Mangioni D; Muscatello A; Aliberti S; Blasi F; De Feo T; Prati D; Manganaro L; Granucci F; Lanzavecchia A; De Francesco R; Gori A; Grifantini R; Abrignani S
  • Sci Immunol 2021[Aug]; 6 (62): ä PMID34376481show ga
  • To understand how a protective immune response against SARS-CoV-2 develops over time, we integrated phenotypic, transcriptional and repertoire analyses on PBMCs from mild and severe COVID-19 patients during and after infection, and compared them to healthy donors (HD). A type I IFN-response signature marked all the immune populations from severe patients during the infection. Humoral immunity was dominated by IgG production primarily against the RBD and N proteins, with neutralizing antibody titers increasing post infection and with disease severity. Memory B cells, including an atypical FCRL5(+) T-BET(+) memory subset, increased during the infection, especially in patients with mild disease. A significant reduction of effector memory, CD8(+) T cells frequency characterized patients with severe disease. Despite such impairment, we observed robust clonal expansion of CD8(+) T lymphocytes, while CD4(+) T cells were less expanded and skewed toward T(CM) and T(H)2-like phenotypes. MAIT cells were also expanded, but only in patients with mild disease. Terminally differentiated CD8(+) GZMB(+) effector cells were clonally expanded both during the infection and post-infection, while CD8(+) GZMK(+) lymphocytes were more expanded post-infection and represented bona fide memory precursor effector cells. TCR repertoire analysis revealed that only highly proliferating T cell clonotypes, which included SARS-CoV-2-specific cells, were maintained post-infection and shared between the CD8(+) GZMB(+) and GZMK(+) subsets. Overall, this study describes the development of immunity against SARS-CoV-2 and identifies an effector CD8(+) T cell population with memory precursor-like features.
  • |*Immunophenotyping[MESH]
  • |*Transcriptome[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/immunology[MESH]
  • |B-Lymphocytes/immunology/metabolism[MESH]
  • |Biomarkers[MESH]
  • |COVID-19/*genetics/*immunology/virology[MESH]
  • |Cell Plasticity/genetics/immunology[MESH]
  • |Clonal Evolution/immunology[MESH]
  • |Female[MESH]
  • |Gene Expression Profiling[MESH]
  • |Host-Pathogen Interactions/*immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Isotypes/immunology[MESH]
  • |Immunologic Memory[MESH]
  • |Leukocytes, Mononuclear/immunology/metabolism[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box