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10.1016/j.chembiol.2021.07.014 http://scihub22266oqcxt.onion/10.1016/j.chembiol.2021.07.014 34375614!8818810!34375614     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Chem+Biol 2022 ; 29 (2): 239-248.e4 Nephropedia Template TP {{tp|p=34375614|t=2022. TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor |pdf=|usr=}}{{34375614}} gab.com Text TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor JO: Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=34375614 #FOAvip Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease-associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathway has been implicated in a variety of diseases ranging from neurodegeneration in the central nervous system to metabolic disease in the periphery. Here, we report that TREM2 is a thyroid hormone-regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone and synthetic thyroid hormone agonists (thyromimetics). Our findings report the endocrine regulation of TREM2 by thyroid hormone, and provide a unique opportunity to drug the TREM2 signaling pathway with orally active small-molecule therapeutic agents. Twit Text FOAVip TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor ????Cell Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=34375614 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34375614 #FOAvip English Wikipedia <ref>{{Cite pmid|34375614}}</ref> TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor #MMPMID34375614 Ferrara SJ; Chaudhary P; DeBell MJ; Marracci G; Miller H; Calkins E; Pocius E; Napier BA; Emery B; Bourdette D; Scanlan TS Cell Chem Biol 2022[Feb]; 29 (2): 239-248.e4 PMID34375614show ga Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease-associated signals to regulate the phenotype of these innate immune cells. The TREM2 signaling pathway has been implicated in a variety of diseases ranging from neurodegeneration in the central nervous system to metabolic disease in the periphery. Here, we report that TREM2 is a thyroid hormone-regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone and synthetic thyroid hormone agonists (thyromimetics). Our findings report the endocrine regulation of TREM2 by thyroid hormone, and provide a unique opportunity to drug the TREM2 signaling pathway with orally active small-molecule therapeutic agents. |Acetates/chemical synthesis/*pharmacology[MESH] |Animals[MESH] |Binding Sites[MESH] |Brain/drug effects/immunology/pathology[MESH] |Encephalomyelitis, Autoimmune, Experimental/*drug therapy/genetics/immunology/pathology[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Macrophages/drug effects/immunology/pathology[MESH] |Membrane Glycoproteins/antagonists & inhibitors/*genetics/immunology[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Microglia/*drug effects/immunology/pathology[MESH] |Models, Molecular[MESH] |Phenols/chemical synthesis/*pharmacology[MESH] |Phenoxyacetates/pharmacology[MESH] |Promoter Regions, Genetic[MESH] |Protein Binding[MESH] |Protein Conformation, alpha-Helical[MESH] |Protein Conformation, beta-Strand[MESH] |Protein Interaction Domains and Motifs[MESH] |RNA, Messenger/antagonists & inhibitors/genetics/immunology[MESH] |Receptors, Immunologic/antagonists & inhibitors/*genetics/immunology[MESH] |Response Elements[MESH] |Retinoid X Receptors/chemistry/*genetics/metabolism[MESH] |Signal Transduction[MESH]TREM2 is thyroid hormone regulated making the TREM2 pathway druggable (epmc).pdf DeepDyve Pubget Overpricing