Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s10787-021-00860-5 http://scihub22266oqcxt.onion/10.1007/s10787-021-00860-5 34373972!8352144!34373972     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Inflammopharmacology 2021 ; 29 (5): 1347-1355 Nephropedia Template TP {{tp|p=34373972|t=2021. Management of COVID-19-induced ?cytokine ?storm by Keap1-Nrf2 system: a? r?eview |pdf=|usr=}}{{34373972}} gab.com Text Management of COVID-19-induced cytokine storm by Keap1-Nrf2 system: a r eview JO: Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=34373972 #FOAvip The natural pathway of antioxidant production is mediated through Kelch-like erythroid cell-derived protein with Cap and collar homology [ECH]-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2) system. Keap1 maintains a low level of Nrf2 by holding it in its protein complex. Also, Keap1 facilitates the degradation of Nrf2 by ubiquitination. In other words, Keap1 is a down-regulator of Nrf2. To boost the production of biological antioxidants, Keap1 has to be inhibited and Nrf2 has to be released. Liberated Nrf2 is in an unbound state, so it travels to the nucleus to stimulate the antioxidant response element (ARE) present on the antioxidant genes. AREs activate biosynthesis of biological antioxidants through genes responsible for the production of antioxidants. In some cases of coronavirus disease 2019 (COVID-19), there is an enormous release of cytokines. The antioxidant defense mechanism in the body helps in counteracting symptoms induced by the cytokine storm in COVID-19. So, boosting the production of antioxidants is highly desirable in such a condition. In this review article, we have compiled the role of Keap1-Nrf2 system in antioxidant production. We further propose its potential therapeutic use in managing cytokine storm in COVID-19. Twit Text FOAVip Management of COVID-19-induced cytokine storm by Keap1-Nrf2 system: a r eview ????Inflammopharmacology http://www.kidney.de/pget.php?&tw=1&pmid=34373972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34373972 #FOAvip English Wikipedia <ref>{{Cite pmid|34373972}}</ref> Management of COVID-19-induced ?cytokine ?storm by Keap1-Nrf2 system: a? r?eview #MMPMID34373972 Singh E; Matada GSP; Abbas N; Dhiwar PS; Ghara A; Das A Inflammopharmacology 2021[Oct]; 29 (5): 1347-1355 PMID34373972show ga The natural pathway of antioxidant production is mediated through Kelch-like erythroid cell-derived protein with Cap and collar homology [ECH]-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2) system. Keap1 maintains a low level of Nrf2 by holding it in its protein complex. Also, Keap1 facilitates the degradation of Nrf2 by ubiquitination. In other words, Keap1 is a down-regulator of Nrf2. To boost the production of biological antioxidants, Keap1 has to be inhibited and Nrf2 has to be released. Liberated Nrf2 is in an unbound state, so it travels to the nucleus to stimulate the antioxidant response element (ARE) present on the antioxidant genes. AREs activate biosynthesis of biological antioxidants through genes responsible for the production of antioxidants. In some cases of coronavirus disease 2019 (COVID-19), there is an enormous release of cytokines. The antioxidant defense mechanism in the body helps in counteracting symptoms induced by the cytokine storm in COVID-19. So, boosting the production of antioxidants is highly desirable in such a condition. In this review article, we have compiled the role of Keap1-Nrf2 system in antioxidant production. We further propose its potential therapeutic use in managing cytokine storm in COVID-19. |Animals[MESH] |Antioxidants/metabolism/pharmacology/therapeutic use[MESH] |COVID-19/*metabolism/*therapy[MESH] |Cytokine Release Syndrome/*metabolism/*therapy[MESH] |Disease Management[MESH] |Humans[MESH] |Kelch-Like ECH-Associated Protein 1/antagonists & inhibitors/*metabolism[MESH] |NF-E2-Related Factor 2/agonists/*metabolism[MESH]Management of COVID-19-induced ?cytokine ?storm by Keap1-Nrf2 system: (epmc).pdf DeepDyve Pubget Overpricing