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10.1016/j.cct.2021.106525 http://scihub22266oqcxt.onion/10.1016/j.cct.2021.106525 34371163!8349387!34371163     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Contemp+Clin+Trials 2021 ; 109 (ä): 106525 Nephropedia Template TP {{tp|p=34371163|t=2021. Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform |pdf=|usr=}}{{34371163}} gab.com Text Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform JO: Contemp Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=34371163 #FOAvip BACKGROUND: The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and prevention. DESIGN: An online research platform was created to support a registry community of healthcare workers (HCWs) to understand their experiences and conduct clinical studies to address their concerns. The first study, HERO-HCQ, was a double-blind, multicenter, randomized, pragmatic trial to evaluate the superiority of hydroxychloroquine (HCQ) vs placebo for pre-exposure prophylaxis (PrEP) of COVID-19 clinical infection in HCWs. Secondary objectives were to assess the efficacy of HCQ in preventing viral shedding of COVID-19 among HCWs and to assess the safety and tolerability of HCQ. METHODS: HCWs joined the Registry and were pre-screened for trial interest and eligibility. Trial participants were randomized 1:1 to receive HCQ or placebo. On-site baseline assessment included a COVID-19 nasopharyngeal PCR and blood serology test. Weekly follow-up was done via an online portal and included screening for symptoms of COVID-19, self-reported testing, adverse events, and quality of life assessments. The on-site visit was repeated at Day 30. DISCUSSION: The HERO research platform offers an approach to rapidly engage, screen, invite and enroll into clinical studies using a novel participant-facing online portal interface and remote data collection, enabling limited onsite procedures for conduct of a pragmatic clinical trial. This platform may be an example for future clinical trials of common conditions to enable more rapid evidence generation. Twit Text FOAVip Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform ????Contemp Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=34371163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34371163 #FOAvip English Wikipedia <ref>{{Cite pmid|34371163}}</ref> Design of the Healthcare Worker Exposure Response and Outcomes (HERO) research platform #MMPMID34371163 Friedland A; Hernandez AF; Anstrom KJ; Chen-Lim ML; Cohen LW; Currier JS; Forrest CB; Fraser R; Fraulo E; George A; Handberg E; Jackman J; Koellhoffer J; Lawrence D; Leverty R; McAdams P; McCourt B; Mickley B; Naqvi SH; O'Brien EC; Olson R; Prater C; Rothman RL; Shenkman E; Shostak J; Turner KB; Webb L; Woods C; Naggie S Contemp Clin Trials 2021[Oct]; 109 (ä): 106525 PMID34371163show ga BACKGROUND: The SARS CoV-2 virus has caused one of the deadliest pandemics in recent history, resulting in over 170 million deaths and global economic disruption. There remains an urgent need for clinical trials to test therapies for treatment and prevention. DESIGN: An online research platform was created to support a registry community of healthcare workers (HCWs) to understand their experiences and conduct clinical studies to address their concerns. The first study, HERO-HCQ, was a double-blind, multicenter, randomized, pragmatic trial to evaluate the superiority of hydroxychloroquine (HCQ) vs placebo for pre-exposure prophylaxis (PrEP) of COVID-19 clinical infection in HCWs. Secondary objectives were to assess the efficacy of HCQ in preventing viral shedding of COVID-19 among HCWs and to assess the safety and tolerability of HCQ. METHODS: HCWs joined the Registry and were pre-screened for trial interest and eligibility. Trial participants were randomized 1:1 to receive HCQ or placebo. On-site baseline assessment included a COVID-19 nasopharyngeal PCR and blood serology test. Weekly follow-up was done via an online portal and included screening for symptoms of COVID-19, self-reported testing, adverse events, and quality of life assessments. The on-site visit was repeated at Day 30. DISCUSSION: The HERO research platform offers an approach to rapidly engage, screen, invite and enroll into clinical studies using a novel participant-facing online portal interface and remote data collection, enabling limited onsite procedures for conduct of a pragmatic clinical trial. This platform may be an example for future clinical trials of common conditions to enable more rapid evidence generation. |*COVID-19[MESH] |*Quality of Life[MESH] |Health Personnel[MESH] |Humans[MESH] |SARS-CoV-2[MESH]Design of the Healthcare Worker Exposure Response and Outcomes (HERO) (epmc).pdf DeepDyve Pubget Overpricing