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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 ACS+Omega 2021 ; 6 (30): 19356-19363 Nephropedia Template TP
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Evolution of the Synthesis of Remdesivir Classical Approaches and Most Recent Advances #MMPMID34368522
Vargas DF; Larghi EL; Kaufman TS
ACS Omega 2021[Aug]; 6 (30): 19356-19363 PMID34368522show ga
The broad-spectrum antiviral Remdesivir, a monophosphate nucleoside analogue prodrug (ProTide), was repurposed. In May 2020, it received emergency approval by the FDA, being the first drug approved to fight the new coronavirus (COVID-19) disease which targets the virus directly. The main synthetic strategies toward Remdesivir, and their relevant modifications, are presented and discussed, to provide a panoramic view of the state-of-the-art and the more important advances in this field. Recent progress, proposed improvements, and uses of novel technologies for the synthetic sequence are also detailed.