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10.3389/fimmu.2021.719544 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.719544 34367188!8343229!34367188     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 719544 Nephropedia Template TP {{tp|p=34367188|t=2021. Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-Onset Still s Disease From COVID-19 |pdf=|usr=}}{{34367188}} gab.com Text Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-Onset Still s Disease From COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34367188 #FOAvip BACKGROUND: Hyperinflammation with dysregulated production of galectins and cytokines may develop in COVID-19 or adult-onset Still's disease (AOSD). Given the similar clinical features in both diseases, it is necessary to identify biomarkers that can differentiate COVID-19 from AOSD. However, the related data remain scarce currently. METHODS: In this cross-sectional study, plasma levels of galectin-3, galectin-9, and soluble TIM-3 (sTIM-3) were determined by ELISA in 55 COVID-19 patients (31 non-severe and 24 severe), 23 active AOSD patients, and 31 healthy controls (HC). The seropositivity for SARS-CoV-2 was examined using an immunochromatographic assay, and cytokine profiles were determined with the MULTIPLEX platform. RESULTS: Significantly higher levels of galectin-3, galectin-9, IL-1beta, IL-1Ra, IL-10, IFN-alpha2, IL-6, IL-18, and TNF-alpha were observed in severe COVID-19 and active AOSD patients compared with HC (all p<0.001). AOSD, but not COVID-19, showed significantly higher IFN-gamma and IL-17A compared with HC (both p<0.01). Moreover, active AOSD patients had 68-fold higher IL-18 levels and 5-fold higher ferritin levels than severe COVID-19 patients (both p<0.001). IL-18 levels at the cut-off value 190.5pg/mL had the highest discriminative power for active AOSD and severe COVID-19, with AUC 0.948, sensitivity 91.3%, specificity 95.8%, and accuracy of 91.5% (p<0.005). Multivariate regression analysis revealed IL-18 as a significant predictor of active AOSD (p<0.05). CONCLUSION: Active AOSD patients share features of hyperinflammation and cytokine storm with severe COVID-19 patients but possess a distinct cytokine profile, including elevated IL-18, IL-6, IFN-gamma, and IL-17A. IL-18 is a potential discriminator between AOSD and COVID-19 and may significantly predict active AOSD. Twit Text FOAVip Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-Onset Still s Disease From COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34367188 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34367188 #FOAvip English Wikipedia <ref>{{Cite pmid|34367188}}</ref> Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-Onset Still s Disease From COVID-19 #MMPMID34367188 Chen PK; Lan JL; Huang PH; Hsu JL; Chang CK; Tien N; Lin HJ; Chen DY Front Immunol 2021[]; 12 (ä): 719544 PMID34367188show ga BACKGROUND: Hyperinflammation with dysregulated production of galectins and cytokines may develop in COVID-19 or adult-onset Still's disease (AOSD). Given the similar clinical features in both diseases, it is necessary to identify biomarkers that can differentiate COVID-19 from AOSD. However, the related data remain scarce currently. METHODS: In this cross-sectional study, plasma levels of galectin-3, galectin-9, and soluble TIM-3 (sTIM-3) were determined by ELISA in 55 COVID-19 patients (31 non-severe and 24 severe), 23 active AOSD patients, and 31 healthy controls (HC). The seropositivity for SARS-CoV-2 was examined using an immunochromatographic assay, and cytokine profiles were determined with the MULTIPLEX platform. RESULTS: Significantly higher levels of galectin-3, galectin-9, IL-1beta, IL-1Ra, IL-10, IFN-alpha2, IL-6, IL-18, and TNF-alpha were observed in severe COVID-19 and active AOSD patients compared with HC (all p<0.001). AOSD, but not COVID-19, showed significantly higher IFN-gamma and IL-17A compared with HC (both p<0.01). Moreover, active AOSD patients had 68-fold higher IL-18 levels and 5-fold higher ferritin levels than severe COVID-19 patients (both p<0.001). IL-18 levels at the cut-off value 190.5pg/mL had the highest discriminative power for active AOSD and severe COVID-19, with AUC 0.948, sensitivity 91.3%, specificity 95.8%, and accuracy of 91.5% (p<0.005). Multivariate regression analysis revealed IL-18 as a significant predictor of active AOSD (p<0.05). CONCLUSION: Active AOSD patients share features of hyperinflammation and cytokine storm with severe COVID-19 patients but possess a distinct cytokine profile, including elevated IL-18, IL-6, IFN-gamma, and IL-17A. IL-18 is a potential discriminator between AOSD and COVID-19 and may significantly predict active AOSD. |*COVID-19/blood/immunology[MESH] |*Interleukin-18/blood/immunology[MESH] |*SARS-CoV-2/immunology/metabolism[MESH] |*Still's Disease, Adult-Onset/blood/immunology[MESH] |Adult[MESH] |Biomarkers/blood[MESH] |Cross-Sectional Studies[MESH] |Female[MESH] |Humans[MESH]Interleukin-18 Is a Potential Biomarker to Discriminate Active Adult-O(epmc).pdf DeepDyve Pubget Overpricing