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10.3389/fimmu.2021.690534 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.690534 34367150!8343175!34367150     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 690534 Nephropedia Template TP {{tp|p=34367150|t=2021. Evolution of Human Memory B Cells From Childhood to Old Age |pdf=|usr=}}{{34367150}} gab.com Text Evolution of Human Memory B Cells From Childhood to Old Age JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34367150 #FOAvip High quality medical assistance and preventive strategies, including pursuing a healthy lifestyle, result in a progressively growing percentage of older people. The population and workforce is aging in all countries of the world. It is widely recognized that older individuals show an increased susceptibility to infections and a reduced response to vaccination suggesting that the aged immune system is less able to react and consequently protect the organism. The SARS-CoV-2 pandemic is dramatically showing us that the organism reacts to novel pathogens in an age-dependent manner. The decline of the immune system observed in aging remains unclear. We aimed to understand the role of B cells. We analyzed peripheral blood from children (4-18 years); young people (23-60 years) and elderly people (65-91 years) by flow cytometry. We also measured antibody secretion by ELISA following a T-independent stimulation. Here we show that the elderly have a significant reduction of CD27(dull) memory B cells, a population that bridges innate and adaptive immune functions. In older people, memory B cells are mostly high specialized antigen-selected CD27(bright). Moreover, after in vitro stimulation with CpG, B cells from older individuals produced significantly fewer IgM and IgA antibodies compared to younger individuals. Aging is a complex process characterized by a functional decline in multiple physiological systems. The immune system of older people is well equipped to react to often encountered antigens but has a low ability to respond to new pathogens. Twit Text FOAVip Evolution of Human Memory B Cells From Childhood to Old Age ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34367150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34367150 #FOAvip English Wikipedia <ref>{{Cite pmid|34367150}}</ref> Evolution of Human Memory B Cells From Childhood to Old Age #MMPMID34367150 Ciocca M; Zaffina S; Fernandez Salinas A; Bocci C; Palomba P; Conti MG; Terreri S; Frisullo G; Giorda E; Scarsella M; Brugaletta R; Vinci MR; Magnavita N; Carsetti R; Piano Mortari E Front Immunol 2021[]; 12 (ä): 690534 PMID34367150show ga High quality medical assistance and preventive strategies, including pursuing a healthy lifestyle, result in a progressively growing percentage of older people. The population and workforce is aging in all countries of the world. It is widely recognized that older individuals show an increased susceptibility to infections and a reduced response to vaccination suggesting that the aged immune system is less able to react and consequently protect the organism. The SARS-CoV-2 pandemic is dramatically showing us that the organism reacts to novel pathogens in an age-dependent manner. The decline of the immune system observed in aging remains unclear. We aimed to understand the role of B cells. We analyzed peripheral blood from children (4-18 years); young people (23-60 years) and elderly people (65-91 years) by flow cytometry. We also measured antibody secretion by ELISA following a T-independent stimulation. Here we show that the elderly have a significant reduction of CD27(dull) memory B cells, a population that bridges innate and adaptive immune functions. In older people, memory B cells are mostly high specialized antigen-selected CD27(bright). Moreover, after in vitro stimulation with CpG, B cells from older individuals produced significantly fewer IgM and IgA antibodies compared to younger individuals. Aging is a complex process characterized by a functional decline in multiple physiological systems. The immune system of older people is well equipped to react to often encountered antigens but has a low ability to respond to new pathogens. |*COVID-19/epidemiology/immunology[MESH] |*Immunologic Memory[MESH] |*Pandemics[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Aging/*immunology[MESH] |B-Lymphocytes/*immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cytokines/immunology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/immunology[MESH] |Immunoglobulin M/immunology[MESH] |Male[MESH] |Middle Aged[MESH]Evolution of Human Memory B Cells From Childhood to Old Age (epmc).pdf DeepDyve Pubget Overpricing