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10.3389/fphys.2021.688946 http://scihub22266oqcxt.onion/10.3389/fphys.2021.688946 34366882!8339726!34366882     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2021 ; 12 (ä): 688946 Nephropedia Template TP {{tp|p=34366882|t=2021. The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza |pdf=|usr=}}{{34366882}} gab.com Text The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34366882 #FOAvip In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordinated type I response and instead may lead to exaggerated inflammation and death. This knowledge is central for the understanding of available data on specialized pro-resolving lipid mediators in severe SARS-CoV-2 infection pointing toward inhibited E-series resolvin synthesis in severe cases. By investigating a publicly available RNA-seq database of bronchoalveolar lavage cells from patients affected by COVID-19, we moreover offer insights into the regulation of key enzymes involved in lipid mediator synthesis, critically complementing the current knowledge about the mediator lipidome in severely affected patients. This review finally discusses different potential approaches to sustain the synthesis of 3-PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19. Twit Text FOAVip The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=34366882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34366882 #FOAvip English Wikipedia <ref>{{Cite pmid|34366882}}</ref> The Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 and Influenza #MMPMID34366882 Sahanic S; Loffler-Ragg J; Tymoszuk P; Hilbe R; Demetz E; Masanetz RK; Theurl M; Holfeld J; Gollmann-Tepekoylu C; Tzankov A; Weiss G; Giera M; Tancevski I Front Physiol 2021[]; 12 (ä): 688946 PMID34366882show ga In this review, we discuss spatiotemporal kinetics and inflammatory signatures of innate immune cells specifically found in response to SARS-CoV-2 compared to influenza virus infection. Importantly, we cover the current understanding on the mechanisms by which SARS-CoV-2 may fail to engage a coordinated type I response and instead may lead to exaggerated inflammation and death. This knowledge is central for the understanding of available data on specialized pro-resolving lipid mediators in severe SARS-CoV-2 infection pointing toward inhibited E-series resolvin synthesis in severe cases. By investigating a publicly available RNA-seq database of bronchoalveolar lavage cells from patients affected by COVID-19, we moreover offer insights into the regulation of key enzymes involved in lipid mediator synthesis, critically complementing the current knowledge about the mediator lipidome in severely affected patients. This review finally discusses different potential approaches to sustain the synthesis of 3-PUFA-derived pro-resolving lipid mediators, including resolvins and lipoxins, which may critically aid in the prevention of acute lung injury and death from COVID-19. äThe Role of Innate Immunity and Bioactive Lipid Mediators in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing