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10.1016/j.dsx.2021.102238

http://scihub22266oqcxt.onion/10.1016/j.dsx.2021.102238
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suck abstract from ncbi


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pmid34364299      Diabetes+Metab+Syndr 2021 ; 15 (5): 102238
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  • Evaluation of the dose-effect association between the number of doses and duration since the last dose of COVID-19 vaccine, and its efficacy in preventing the disease and reducing disease severity: A single centre, cross-sectional analytical study from India #MMPMID34364299
  • Bhattacharya A; Ranjan P; Ghosh T; Agarwal H; Seth S; Maher GT; Upadhyay AD; Kumar A; Baitha U; Gupta G; Prakash B; Dwivedi SN; Wig N
  • Diabetes Metab Syndr 2021[Sep]; 15 (5): 102238 PMID34364299show ga
  • AIMS: To evaluate the dose-effect association between COVID-19 vaccination and probability of turning RT-PCR positive and to assess the correlation between disease severity and vaccination status. METHODS: A single centre cross-sectional study was conducted amongst 583 individuals presenting to COVID-19 testing clinic and 55 hospitalized COVID-19 patients. Vaccination status was assessed by the number of doses and duration since the last dose. Disease severity was evaluated by the requirement of hospitalisation and ICU admission/death. The association between the vaccination status and development of disease and its severity were statistically analyzed. RESULTS: The mean age of the population was 36.6 years and 82.6% had no comorbidities. The odds of turning RT-PCR positive was 0.17(95% CI: 0.11-0.27) among the clinical suspects who had taken both doses of the vaccine at least 14 days before (fully vaccinated). The odds of hospitalisation was 0.12(95% CI: 0.03-0.45) and ICU admission/death was 0.07(95% CI: 0.01-0.36) among fully vaccinated individuals. The protective role of vaccination was observed to start 14 days after receiving the first dose. CONCLUSIONS: COVID-19 vaccination provides dose-dependent protection against the development of the disease. It also lowers the risk of hospitalisation and ICU admission/death in RT-PCR positive patients in a dose-dependent manner.
  • |Adult[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines/*administration & dosage[MESH]
  • |COVID-19/diagnosis/epidemiology/*pathology/*prevention & control[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Drug Administration Schedule[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Immunization Schedule[MESH]
  • |India/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Severity of Illness Index[MESH]
  • |Time Factors[MESH]
  • |Treatment Outcome[MESH]
  • |Vaccination/statistics & numerical data[MESH]
  • |Vaccine Potency[MESH]


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