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10.1016/j.antiviral.2021.105158 http://scihub22266oqcxt.onion/10.1016/j.antiviral.2021.105158 34363859!9012257!34363859     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Antiviral+Res 2021 ; 194 (ä): 105158 Nephropedia Template TP {{tp|p=34363859|t=2021. Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group |pdf=|usr=}}{{34363859}} gab.com Text Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group JO: Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34363859 #FOAvip It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymerase inhibitors and recent approval of baloxavir marboxil, the isirv-AVG held a closed meeting in August 2019 to discuss the impact of resistance to these inhibitors. Following this meeting and review of the current literature, this article is intended to summarize current knowledge regarding the clinical impact of resistance to polymerase inhibitors and approaches for surveillance and methods for laboratory evaluation of resistance, both in vitro and in animal models. We highlight limitations and gaps in current knowledge and suggest some strategies for addressing these gaps, including the need for additional clinical studies of influenza antiviral drug combinations. Lessons learned from influenza resistance monitoring may also be helpful for establishing future drug susceptibility surveillance and testing for SARS-CoV-2. Twit Text FOAVip Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group ????Antiviral Res http://www.kidney.de/pget.php?&tw=1&pmid=34363859 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34363859 #FOAvip English Wikipedia <ref>{{Cite pmid|34363859}}</ref> Influenza polymerase inhibitor resistance: Assessment of the current state of the art - A report of the isirv Antiviral group #MMPMID34363859 Ison MG; Hayden FG; Hay AJ; Gubareva LV; Govorkova EA; Takashita E; McKimm-Breschkin JL Antiviral Res 2021[Oct]; 194 (ä): 105158 PMID34363859show ga It is more than 20 years since the neuraminidase inhibitors, oseltamivir and zanamivir were approved for the treatment and prevention of influenza. Guidelines for global surveillance and methods for evaluating resistance were established initially by the Neuraminidase Inhibitor Susceptibility Network (NISN), which merged 10 years ago with the International Society for influenza and other Respiratory Virus Diseases (isirv) to become the isirv-Antiviral Group (isirv-AVG). With the ongoing development of new influenza polymerase inhibitors and recent approval of baloxavir marboxil, the isirv-AVG held a closed meeting in August 2019 to discuss the impact of resistance to these inhibitors. Following this meeting and review of the current literature, this article is intended to summarize current knowledge regarding the clinical impact of resistance to polymerase inhibitors and approaches for surveillance and methods for laboratory evaluation of resistance, both in vitro and in animal models. We highlight limitations and gaps in current knowledge and suggest some strategies for addressing these gaps, including the need for additional clinical studies of influenza antiviral drug combinations. Lessons learned from influenza resistance monitoring may also be helpful for establishing future drug susceptibility surveillance and testing for SARS-CoV-2. |Animals[MESH] |Antiviral Agents/adverse effects/pharmacology/*therapeutic use[MESH] |Dibenzothiepins/pharmacology[MESH] |Drug Resistance, Viral[MESH] |Enzyme Inhibitors/pharmacology[MESH] |Humans[MESH] |Influenza, Human/*drug therapy/virology[MESH] |Knowledge[MESH] |Morpholines/pharmacology[MESH] |Neuraminidase/therapeutic use[MESH] |Oseltamivir/pharmacology[MESH] |Pyridones/pharmacology[MESH] |SARS-CoV-2/drug effects[MESH] |Triazines/pharmacology[MESH] |Virus Replication/drug effects[MESH]Influenza polymerase inhibitor resistance: Assessment of the current s(epmc).pdf DeepDyve Pubget Overpricing