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10.3390/ijms22158012 http://scihub22266oqcxt.onion/10.3390/ijms22158012 34360778!8347560!34360778     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34360778&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34360778.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2021 ; 22 (15): ä Nephropedia Template TP {{tp|p=34360778|t=2021. Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome |pdf=|usr=}}{{34360778}} gab.com Text Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34360778 #FOAvip G-quadruplexes are the non-canonical nucleic acid structures that are preferentially formed in G-rich regions. This structure has been shown to be associated with many biological functions. Regardless of the broad efforts on DNA G-quadruplexes, we still have limited knowledge on RNA G-quadruplexes, especially in a transcriptome-wide manner. Herein, by integrating the DMS-seq and the bioinformatics pipeline, we profiled and depicted the RNA G-quadruplexes in the human transcriptome. The genes that contain RNA G-quadruplexes in their specific regions are significantly related to immune pathways and the COVID-19-related gene sets. Bioinformatics analysis reveals the potential regulatory functions of G-quadruplexes on miRNA targeting at the scale of the whole transcriptome. In addition, the G-quadruplexes are depleted in the putative, not the real, PAS-strong poly(A) sites, which may weaken the possibility of such sites being the real cleaved sites. In brief, our study provides insight into the potential function of RNA G-quadruplexes in post-transcription. Twit Text FOAVip Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34360778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34360778 #FOAvip English Wikipedia <ref>{{Cite pmid|34360778}}</ref> Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome #MMPMID34360778 Zhang R; Liu Y; Zhang X; Xiao K; Hou Y; Liu H; Sun X Int J Mol Sci 2021[Jul]; 22 (15): ä PMID34360778show ga G-quadruplexes are the non-canonical nucleic acid structures that are preferentially formed in G-rich regions. This structure has been shown to be associated with many biological functions. Regardless of the broad efforts on DNA G-quadruplexes, we still have limited knowledge on RNA G-quadruplexes, especially in a transcriptome-wide manner. Herein, by integrating the DMS-seq and the bioinformatics pipeline, we profiled and depicted the RNA G-quadruplexes in the human transcriptome. The genes that contain RNA G-quadruplexes in their specific regions are significantly related to immune pathways and the COVID-19-related gene sets. Bioinformatics analysis reveals the potential regulatory functions of G-quadruplexes on miRNA targeting at the scale of the whole transcriptome. In addition, the G-quadruplexes are depleted in the putative, not the real, PAS-strong poly(A) sites, which may weaken the possibility of such sites being the real cleaved sites. In brief, our study provides insight into the potential function of RNA G-quadruplexes in post-transcription. |*G-Quadruplexes[MESH] |COVID-19/genetics[MESH] |Cell Line[MESH] |Computational Biology[MESH] |Gene Expression Profiling[MESH] |Humans[MESH] |MicroRNAs/chemistry/metabolism[MESH] |Poly A/genetics[MESH] |SARS-CoV-2/genetics/metabolism[MESH] |Transcriptome/*genetics[MESH]Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Tra(epmc).pdf DeepDyve Pubget Overpricing