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10.3390/ijms22158012

http://scihub22266oqcxt.onion/10.3390/ijms22158012
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34360778!8347560!34360778
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suck abstract from ncbi


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pmid34360778      Int+J+Mol+Sci 2021 ; 22 (15): ä
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  • Detecting and Profiling Endogenous RNA G-Quadruplexes in the Human Transcriptome #MMPMID34360778
  • Zhang R; Liu Y; Zhang X; Xiao K; Hou Y; Liu H; Sun X
  • Int J Mol Sci 2021[Jul]; 22 (15): ä PMID34360778show ga
  • G-quadruplexes are the non-canonical nucleic acid structures that are preferentially formed in G-rich regions. This structure has been shown to be associated with many biological functions. Regardless of the broad efforts on DNA G-quadruplexes, we still have limited knowledge on RNA G-quadruplexes, especially in a transcriptome-wide manner. Herein, by integrating the DMS-seq and the bioinformatics pipeline, we profiled and depicted the RNA G-quadruplexes in the human transcriptome. The genes that contain RNA G-quadruplexes in their specific regions are significantly related to immune pathways and the COVID-19-related gene sets. Bioinformatics analysis reveals the potential regulatory functions of G-quadruplexes on miRNA targeting at the scale of the whole transcriptome. In addition, the G-quadruplexes are depleted in the putative, not the real, PAS-strong poly(A) sites, which may weaken the possibility of such sites being the real cleaved sites. In brief, our study provides insight into the potential function of RNA G-quadruplexes in post-transcription.
  • |*G-Quadruplexes[MESH]
  • |COVID-19/genetics[MESH]
  • |Cell Line[MESH]
  • |Computational Biology[MESH]
  • |Gene Expression Profiling[MESH]
  • |Humans[MESH]
  • |MicroRNAs/chemistry/metabolism[MESH]
  • |Poly A/genetics[MESH]
  • |SARS-CoV-2/genetics/metabolism[MESH]
  • |Transcriptome/*genetics[MESH]


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