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10.3390/ijms22157954 http://scihub22266oqcxt.onion/10.3390/ijms22157954 34360716!8347150!34360716     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (15): ä Nephropedia Template TP {{tp|p=34360716|t=2021. Impact of Hypoxia over Human Viral Infections and Key Cellular Processes |pdf=|usr=}}{{34360716}} gab.com Text Impact of Hypoxia over Human Viral Infections and Key Cellular Processes JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34360716 #FOAvip Oxygen is essential for aerobic cells, and thus its sensing is critical for the optimal maintenance of vital cellular and tissue processes such as metabolism, pH homeostasis, and angiogenesis, among others. Hypoxia-inducible factors (HIFs) play central roles in oxygen sensing. Under hypoxic conditions, the alpha subunit of HIFs is stabilized and forms active heterodimers that translocate to the nucleus and regulate the expression of important sets of genes. This process, in turn, will induce several physiological changes intended to adapt to these new and adverse conditions. Over the last decades, numerous studies have reported a close relationship between viral infections and hypoxia. Interestingly, this relation is somewhat bidirectional, with some viruses inducing a hypoxic response to promote their replication, while others inhibit hypoxic cellular responses. Here, we review and discuss the cellular responses to hypoxia and discuss how HIFs can promote a wide range of physiological and transcriptional changes in the cell that modulate numerous human viral infections. Twit Text FOAVip Impact of Hypoxia over Human Viral Infections and Key Cellular Processes ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=34360716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34360716 #FOAvip English Wikipedia <ref>{{Cite pmid|34360716}}</ref> Impact of Hypoxia over Human Viral Infections and Key Cellular Processes #MMPMID34360716 Reyes A; Duarte LF; Farias MA; Tognarelli E; Kalergis AM; Bueno SM; Gonzalez PA Int J Mol Sci 2021[Jul]; 22 (15): ä PMID34360716show ga Oxygen is essential for aerobic cells, and thus its sensing is critical for the optimal maintenance of vital cellular and tissue processes such as metabolism, pH homeostasis, and angiogenesis, among others. Hypoxia-inducible factors (HIFs) play central roles in oxygen sensing. Under hypoxic conditions, the alpha subunit of HIFs is stabilized and forms active heterodimers that translocate to the nucleus and regulate the expression of important sets of genes. This process, in turn, will induce several physiological changes intended to adapt to these new and adverse conditions. Over the last decades, numerous studies have reported a close relationship between viral infections and hypoxia. Interestingly, this relation is somewhat bidirectional, with some viruses inducing a hypoxic response to promote their replication, while others inhibit hypoxic cellular responses. Here, we review and discuss the cellular responses to hypoxia and discuss how HIFs can promote a wide range of physiological and transcriptional changes in the cell that modulate numerous human viral infections. |*Oxygen Consumption[MESH] |*Virus Replication[MESH] |Cell Hypoxia[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1/*metabolism[MESH] |Virus Diseases/*metabolism/pathology[MESH]Impact of Hypoxia over Human Viral Infections and Key Cellular Process(epmc).pdf DeepDyve Pubget Overpricing