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10.3390/cells10071788 http://scihub22266oqcxt.onion/10.3390/cells10071788 34359957!8305278!34359957     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34359957.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cells 2021 ; 10 (7): ä Nephropedia Template TP {{tp|p=34359957|t=2021. MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women |pdf=|usr=}}{{34359957}} gab.com Text MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34359957 #FOAvip MicroRNAs are gene expression regulators associated with several human pathologies, including those generated by viral infections. Their role in SARS-CoV-2 infection and COVID-19 has been investigated and reviewed in many informative studies; however, a thorough miRNA outline in SARS-CoV-2-infected pregnant women (SIPW), at both systemic and placental levels, is missing. To fill this gap, blood and placenta biopsies collected at delivery from 15 asymptomatic SIPW were immediately analysed for: miRNA expression (n = 84) (QPCR array), antiviral/immune mRNA target expression (n = 74) (QGene) and cytokine/chemokines production (n = 27) (Multiplex ELISA). By comparing these results with those obtained from six uninfected pregnant women (UPW), we observed that, following SARS-CoV-2 infection, the transcriptomic profile of pregnant women is significantly altered in different anatomical districts, even in the absence of clinical symptoms and vertical transmission. This characteristic combination of miRNA and antiviral/immune factors seems to control both the infection and the dysfunctional immune reaction, thus representing a positive correlate of protection and a potential therapeutic target against SARS-CoV-2. Twit Text FOAVip MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34359957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34359957 #FOAvip English Wikipedia <ref>{{Cite pmid|34359957}}</ref> MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant Women #MMPMID34359957 Saulle I; Garziano M; Fenizia C; Cappelletti G; Parisi F; Clerici M; Cetin I; Savasi V; Biasin M Cells 2021[Jul]; 10 (7): ä PMID34359957show ga MicroRNAs are gene expression regulators associated with several human pathologies, including those generated by viral infections. Their role in SARS-CoV-2 infection and COVID-19 has been investigated and reviewed in many informative studies; however, a thorough miRNA outline in SARS-CoV-2-infected pregnant women (SIPW), at both systemic and placental levels, is missing. To fill this gap, blood and placenta biopsies collected at delivery from 15 asymptomatic SIPW were immediately analysed for: miRNA expression (n = 84) (QPCR array), antiviral/immune mRNA target expression (n = 74) (QGene) and cytokine/chemokines production (n = 27) (Multiplex ELISA). By comparing these results with those obtained from six uninfected pregnant women (UPW), we observed that, following SARS-CoV-2 infection, the transcriptomic profile of pregnant women is significantly altered in different anatomical districts, even in the absence of clinical symptoms and vertical transmission. This characteristic combination of miRNA and antiviral/immune factors seems to control both the infection and the dysfunctional immune reaction, thus representing a positive correlate of protection and a potential therapeutic target against SARS-CoV-2. |Adult[MESH] |COVID-19/blood/diagnosis/*genetics[MESH] |Female[MESH] |Humans[MESH] |MicroRNAs/analysis/blood/*genetics[MESH] |Placenta/metabolism[MESH] |Pregnancy[MESH] |Pregnancy Complications, Infectious/blood/diagnosis/*genetics[MESH] |SARS-CoV-2/isolation & purification[MESH] |Transcriptome[MESH]MiRNA Profiling in Plasma and Placenta of SARS-CoV-2-Infected Pregnant(epmc).pdf DeepDyve Pubget Overpricing