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10.3390/cells10071768 http://scihub22266oqcxt.onion/10.3390/cells10071768 34359938!8307983!34359938     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (7): ä Nephropedia Template TP {{tp|p=34359938|t=2021. Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases |pdf=|usr=}}{{34359938}} gab.com Text Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=34359938 #FOAvip Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain, which has many other activities that have not been fully acknowledged. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca(2+). Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies. This review links structural stability of TTR with the environmental factors, particularly oxidative stress and Ca(2+), and the processes involved in the pathogenesis of TTR-related diseases. The roles of TTR in biomineralization, calcification, and osteoarticular and cardiovascular diseases are broadly discussed. The association of TTR-related diseases and vascular and ligament tissue calcification with TTR levels and TTR structure is presented. It is indicated that unaggregated TTR and TTR amyloid are bound by vicious cycles, and that TTR may have an as yet undetermined role(s) at the crossroads of calcification, blood coagulation, and immune response. Twit Text FOAVip Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=34359938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34359938 #FOAvip English Wikipedia <ref>{{Cite pmid|34359938}}</ref> Transthyretin: From Structural Stability to Osteoarticular and Cardiovascular Diseases #MMPMID34359938 Wieczorek E; Ozyhar A Cells 2021[Jul]; 10 (7): ä PMID34359938show ga Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain, which has many other activities that have not been fully acknowledged. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca(2+). Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies. This review links structural stability of TTR with the environmental factors, particularly oxidative stress and Ca(2+), and the processes involved in the pathogenesis of TTR-related diseases. The roles of TTR in biomineralization, calcification, and osteoarticular and cardiovascular diseases are broadly discussed. The association of TTR-related diseases and vascular and ligament tissue calcification with TTR levels and TTR structure is presented. It is indicated that unaggregated TTR and TTR amyloid are bound by vicious cycles, and that TTR may have an as yet undetermined role(s) at the crossroads of calcification, blood coagulation, and immune response. |Amyloid/chemistry/metabolism[MESH] |Amyloidosis/metabolism[MESH] |Animals[MESH] |Arthritis/*metabolism[MESH] |Cardiovascular Diseases/*metabolism[MESH] |Humans[MESH] |Osteoporosis/*metabolism[MESH] |Oxidative Stress[MESH] |Prealbumin/chemistry/*metabolism[MESH] |Protein Conformation[MESH]Transthyretin: From Structural Stability to Osteoarticular and Cardiov(epmc).pdf DeepDyve Pubget Overpricing