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10.3390/cells10071762

http://scihub22266oqcxt.onion/10.3390/cells10071762
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suck abstract from ncbi


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pmid34359932      Cells 2021 ; 10 (7): ä
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  • Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells #MMPMID34359932
  • Meng F; Siu GK; Mok BW; Sun J; Fung KSC; Lam JY; Wong NK; Gedefaw L; Luo S; Lee TMH; Yip SP; Huang CL
  • Cells 2021[Jul]; 10 (7): ä PMID34359932show ga
  • MicroRNAs (miRNAs) are critical regulators of gene expression that may be used to identify the pathological pathways influenced by disease and cellular interactions. Viral miRNAs (v-miRNAs) encoded by both DNA and RNA viruses induce immune dysregulation, virus production, and disease pathogenesis. Given the absence of effective treatment and the prevalence of highly infective SARS-CoV-2 strains, improved understanding of viral-associated miRNAs could provide novel mechanistic insights into the pathogenesis of COVID-19. In this study, SARS-CoV-2 v-miRNAs were identified by deep sequencing in infected Calu-3 and Vero E6 cell lines. Among the ~0.1% small RNA sequences mapped to the SARS-CoV-2 genome, the top ten SARS-CoV-2 v-miRNAs (including three encoded by the N gene; v-miRNA-N) were selected. After initial screening of conserved v-miRNA-N-28612, which was identified in both SARS-CoV and SARS-CoV-2, its expression was shown to be positively associated with viral load in COVID-19 patients. Further in silico analysis and synthetic-mimic transfection of validated SARS-CoV-2 v-miRNAs revealed novel functional targets and associations with mechanisms of cellular metabolism and biosynthesis. Our findings support the development of v-miRNA-based biomarkers and therapeutic strategies based on improved understanding of the pathophysiology of COVID-19.
  • |*Metabolic Networks and Pathways[MESH]
  • |Animals[MESH]
  • |COVID-19/*metabolism/virology[MESH]
  • |Cell Line[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Nucleocapsid Proteins/*genetics[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |MicroRNAs/*genetics[MESH]
  • |Phosphoproteins/genetics[MESH]
  • |RNA, Viral/*genetics[MESH]
  • |SARS-CoV-2/genetics/*physiology[MESH]


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