Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.bios.2021.113536 http://scihub22266oqcxt.onion/10.1016/j.bios.2021.113536 34358999!8314793!34358999     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biosens+Bioelectron 2021 ; 192 (ä): 113536 Nephropedia Template TP {{tp|p=34358999|t=2021. Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy |pdf=|usr=}}{{34358999}} gab.com Text Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy JO: Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=34358999 #FOAvip The ongoing COVID-19 pandemic stresses the need for widely available diagnostic tests for the presence of SARS-CoV-2 in individuals. Due to the limited availability of vaccines, diagnostic assays which are cheap, easy-to-use at the point-of-need, reliable and fast, are currently the only way to control the pandemic situation. Here we present a diagnostic assay for the detection of pathogen-specific nucleic acids based on changes of the magnetic response of magnetic nanoparticles: The target-mediated hybridization of modified nanoparticles leads to an increase in the hydrodynamic radius. This resulting change in the magnetic behaviour in an ac magnetic field can be measured via magnetic particle spectroscopy (MPS), providing a viable tool for the accurate detection of target nucleic acids. In this work we show that single stranded DNA can be detected in a concentration-dependent manner by these means. In addition to detecting synthetic DNA with an arbitrary sequence in a concentration down to 500 pM, we show that RNA and SARS-CoV-2-specific DNA as well as saliva as a sample medium can be used for an accurate assay. These proof-of-principle experiments show the potential of MPS based assays for the reliable and fast diagnostics of pathogens like SARS-CoV-2 in a point-of-need fashion without the need of complex sample preparation. Twit Text FOAVip Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy ????Biosens Bioelectron http://www.kidney.de/pget.php?&tw=1&pmid=34358999 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34358999 #FOAvip English Wikipedia <ref>{{Cite pmid|34358999}}</ref> Point-of-need detection of pathogen-specific nucleic acid targets using magnetic particle spectroscopy #MMPMID34358999 Rosch EL; Zhong J; Lak A; Liu Z; Etzkorn M; Schilling M; Ludwig F; Viereck T; Lalkens B Biosens Bioelectron 2021[Nov]; 192 (ä): 113536 PMID34358999show ga The ongoing COVID-19 pandemic stresses the need for widely available diagnostic tests for the presence of SARS-CoV-2 in individuals. Due to the limited availability of vaccines, diagnostic assays which are cheap, easy-to-use at the point-of-need, reliable and fast, are currently the only way to control the pandemic situation. Here we present a diagnostic assay for the detection of pathogen-specific nucleic acids based on changes of the magnetic response of magnetic nanoparticles: The target-mediated hybridization of modified nanoparticles leads to an increase in the hydrodynamic radius. This resulting change in the magnetic behaviour in an ac magnetic field can be measured via magnetic particle spectroscopy (MPS), providing a viable tool for the accurate detection of target nucleic acids. In this work we show that single stranded DNA can be detected in a concentration-dependent manner by these means. In addition to detecting synthetic DNA with an arbitrary sequence in a concentration down to 500 pM, we show that RNA and SARS-CoV-2-specific DNA as well as saliva as a sample medium can be used for an accurate assay. These proof-of-principle experiments show the potential of MPS based assays for the reliable and fast diagnostics of pathogens like SARS-CoV-2 in a point-of-need fashion without the need of complex sample preparation. |*Biosensing Techniques[MESH] |*COVID-19[MESH] |*Nucleic Acids[MESH] |Humans[MESH] |Magnetic Phenomena[MESH] |Pandemics[MESH] |RNA, Viral[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH]Point-of-need detection of pathogen-specific nucleic acid targets usin(epmc).pdf DeepDyve Pubget Overpricing