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10.1093/clinchem/hvab148 http://scihub22266oqcxt.onion/10.1093/clinchem/hvab148 34358289!8436384!34358289     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Chem 2021 ; 68 (1): 240-248 Nephropedia Template TP {{tp|p=34358289|t=2021. Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection |pdf=|usr=}}{{34358289}} gab.com Text Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection JO: Clin Chem http://www.kidney.de/pget.php?&tw=1&pmid=34358289 #FOAvip BACKGROUND: Biomarkers have been widely explored for coronavirus disease 2019 diagnosis. Both viral RNA or antigens (Ag) in the respiratory system and antibodies (Ab) in blood are used to identify active infection, transmission risk, and immune response but have limitations. This study investigated the diagnostic utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-Ag) in serum. METHODS: We retrospectively studied 208 randomly selected cases with SARS-CoV-2 infection confirmed by viral RNA test in swabs. N-Ag concentrations were measured in remnant serum samples, compared to viral RNA or Ab results, and correlated to electronic health records for clinical value evaluation. RESULTS: Serum N-Ag was detected during active infection as early as day 2 from symptom onset with a diagnostic sensitivity of 81.5%. Within 1 week of symptom onset, the diagnostic sensitivity and specificity reached 90.9% (95% CI, 85.1%-94.6%) and 98.3% (95% CI, 91.1%-99.9%), respectively. Moreover, serum N-Ag concentration closely correlated to disease severity, reflected by highest level of care, medical interventions, chest imaging, and the length of hospital stays. Longitudinal analysis revealed the simultaneous increase of Abs and decline of N-Ag. CONCLUSIONS: Serum N-Ag is a biomarker for SARS-CoV-2 acute infection with high diagnostic sensitivity and specificity compared to viral RNA in the respiratory system. There is a correlation between serum N-Ag concentrations and disease severity and an inverse relationship of N-Ag and Abs. The diagnostic value of serum N-Ag, as well as technical and practical advantages it could offer, may meet unsatisfied diagnostic and prognostic needs during the pandemic. Twit Text FOAVip Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection ????Clin Chem http://www.kidney.de/pget.php?&tw=1&pmid=34358289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34358289 #FOAvip English Wikipedia <ref>{{Cite pmid|34358289}}</ref> Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection #MMPMID34358289 Zhang Y; Ong CM; Yun C; Mo W; Whitman JD; Lynch KL; Wu AHB Clin Chem 2021[Dec]; 68 (1): 240-248 PMID34358289show ga BACKGROUND: Biomarkers have been widely explored for coronavirus disease 2019 diagnosis. Both viral RNA or antigens (Ag) in the respiratory system and antibodies (Ab) in blood are used to identify active infection, transmission risk, and immune response but have limitations. This study investigated the diagnostic utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid protein (N-Ag) in serum. METHODS: We retrospectively studied 208 randomly selected cases with SARS-CoV-2 infection confirmed by viral RNA test in swabs. N-Ag concentrations were measured in remnant serum samples, compared to viral RNA or Ab results, and correlated to electronic health records for clinical value evaluation. RESULTS: Serum N-Ag was detected during active infection as early as day 2 from symptom onset with a diagnostic sensitivity of 81.5%. Within 1 week of symptom onset, the diagnostic sensitivity and specificity reached 90.9% (95% CI, 85.1%-94.6%) and 98.3% (95% CI, 91.1%-99.9%), respectively. Moreover, serum N-Ag concentration closely correlated to disease severity, reflected by highest level of care, medical interventions, chest imaging, and the length of hospital stays. Longitudinal analysis revealed the simultaneous increase of Abs and decline of N-Ag. CONCLUSIONS: Serum N-Ag is a biomarker for SARS-CoV-2 acute infection with high diagnostic sensitivity and specificity compared to viral RNA in the respiratory system. There is a correlation between serum N-Ag concentrations and disease severity and an inverse relationship of N-Ag and Abs. The diagnostic value of serum N-Ag, as well as technical and practical advantages it could offer, may meet unsatisfied diagnostic and prognostic needs during the pandemic. |*COVID-19/diagnosis[MESH] |Antibodies, Viral/blood[MESH] |COVID-19 Testing/*methods[MESH] |Coronavirus Nucleocapsid Proteins/*blood[MESH] |Humans[MESH] |Nucleocapsid Proteins[MESH] |Phosphoproteins/blood[MESH] |RNA, Viral[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infec(epmc).pdf DeepDyve Pubget Overpricing