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10.3390/vaccines9070734 http://scihub22266oqcxt.onion/10.3390/vaccines9070734 34358150!8310186!34358150     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Vaccines+(Basel) 2021 ; 9 (7): ä Nephropedia Template TP {{tp|p=34358150|t=2021. Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines |pdf=|usr=}}{{34358150}} gab.com Text Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines JO: Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34358150 #FOAvip The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5'-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5'-UTR and the downstream 3'-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Psi) complicates some of these optimization processes because Psi is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly. Twit Text FOAVip Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines ????Vaccines (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=34358150 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34358150 #FOAvip English Wikipedia <ref>{{Cite pmid|34358150}}</ref> Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines #MMPMID34358150 Xia X Vaccines (Basel) 2021[Jul]; 9 (7): ä PMID34358150show ga The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations. Proper optimization of vaccine mRNA can reduce dosage required for each injection leading to more efficient immunization programs. The mRNA components of the vaccine need to have a 5'-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination. Both 5'-UTR and the downstream 3'-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Psi) complicates some of these optimization processes because Psi is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made. I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly. äDetailed Dissection and Critical Evaluation of the Pfizer/BioNTech and(epmc).pdf DeepDyve Pubget Overpricing