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10.1084/jem.20211211 http://scihub22266oqcxt.onion/10.1084/jem.20211211 34357402!8352718!34357402     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34357402&cmd=llinks): Failed to open stream: HTTP request failed! 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Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs |pdf=|usr=}}{{34357402}} gab.com Text Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=34357402 #FOAvip IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2 infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3-dependent IFN-stimulated genes, in mildly symptomatic COVID-19 patients and show its correlation with serum IFN-alpha2 levels, which peak at symptom onset and return to baseline from day 10 onward. Moreover, the nasal IFN-I/III signature correlates with the nasopharyngeal viral load and is associated with the presence of infectious viruses. By contrast, we observe low nasal IFN-I/III scores despite high nasal viral loads in a subset of critically ill COVID-19 patients, which correlates with the presence of autoantibodies (auto-Abs) against IFN-I in both blood and nasopharyngeal mucosa. In addition, functional assays in a reconstituted human airway epithelium model of SARS-CoV-2 infection confirm the role of such auto-Abs in abrogating the antiviral effects of IFN-I, but not those of IFN-III. Thus, IFN-I auto-Abs may compromise not only systemic but also local antiviral IFN-I immunity at the early stages of SARS-CoV-2 infection. Twit Text FOAVip Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=34357402 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34357402 #FOAvip English Wikipedia <ref>{{Cite pmid|34357402}}</ref> Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs #MMPMID34357402 Lopez J; Mommert M; Mouton W; Pizzorno A; Brengel-Pesce K; Mezidi M; Villard M; Lina B; Richard JC; Fassier JB; Cheynet V; Padey B; Duliere V; Julien T; Paul S; Bastard P; Belot A; Bal A; Casanova JL; Rosa-Calatrava M; Morfin F; Walzer T; Trouillet-Assant S J Exp Med 2021[Oct]; 218 (10): ä PMID34357402show ga IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2 infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3-dependent IFN-stimulated genes, in mildly symptomatic COVID-19 patients and show its correlation with serum IFN-alpha2 levels, which peak at symptom onset and return to baseline from day 10 onward. Moreover, the nasal IFN-I/III signature correlates with the nasopharyngeal viral load and is associated with the presence of infectious viruses. By contrast, we observe low nasal IFN-I/III scores despite high nasal viral loads in a subset of critically ill COVID-19 patients, which correlates with the presence of autoantibodies (auto-Abs) against IFN-I in both blood and nasopharyngeal mucosa. In addition, functional assays in a reconstituted human airway epithelium model of SARS-CoV-2 infection confirm the role of such auto-Abs in abrogating the antiviral effects of IFN-I, but not those of IFN-III. Thus, IFN-I auto-Abs may compromise not only systemic but also local antiviral IFN-I immunity at the early stages of SARS-CoV-2 infection. |Adult[MESH] |Aged[MESH] |Animals[MESH] |Antiviral Agents/immunology/pharmacology[MESH] |Autoantibodies/blood/*immunology[MESH] |COVID-19/blood/*immunology/virology[MESH] |Chlorocebus aethiops[MESH] |Female[MESH] |Humans[MESH] |Interferon Type I/*immunology/pharmacology[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |Nasal Cavity/immunology/virology[MESH] |Prospective Studies[MESH] |SARS-CoV-2/*immunology/physiology[MESH] |Vero Cells[MESH] |Viral Load/drug effects/immunology[MESH]Early nasal type I IFN immunity against SARS-CoV-2 is compromised in p(epmc).pdf DeepDyve Pubget Overpricing