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10.3390/biom11071063 http://scihub22266oqcxt.onion/10.3390/biom11071063 34356687!8301851!34356687     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34356687&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomolecules 2021 ; 11 (7): ä Nephropedia Template TP {{tp|p=34356687|t=2021. Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated Vascular Inflammation |pdf=|usr=}}{{34356687}} gab.com Text Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated Vascular Inflammation JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=34356687 #FOAvip We report the case of a 77-year-old woman affected by coronavirus disease-19 (COVID-19) who developed an occlusive arterial disease of the lower limb requiring a left leg amputation. We studied the mechanisms of vascular damage by SARS-CoV-2 by means of a comprehensive multi-technique in situ analysis on the diseased popliteal arterial district, including immunohistochemistry (IHC), transmission electron microscopy (TEM) and miRNA analysis. At histological analyses, we observed a lymphocytic inflammatory infiltrate, oedema and endothelialitis of adventitial vasa vasorum while the media was normal and the intima had only minor changes. The vasa vasorum expressed the ACE2 receptor and factor VIII; compared with the controls, VEGFR2 staining was reduced. TEM analyses showed endothelial injury and numerous Weibel-Palade bodies in the cytoplasm. No coronavirus particle was seen. IL-6 protein and mRNA, together with miR-155-5p and miRs-27a-5p, which can target IL-6, were significantly increased compared with that in the controls. Our case report suggests an involvement of adventitial artery microcirculation by inflammation in the course of COVID-19. Without evident signs of current infection by SARS-CoV-2, endothelial cells show a spectrum of structural and functional alterations that can fuel the cardiovascular complications observed in people infected with SARS-CoV-2. Twit Text FOAVip Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated Vascular Inflammation ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=34356687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34356687 #FOAvip English Wikipedia <ref>{{Cite pmid|34356687}}</ref> Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated Vascular Inflammation #MMPMID34356687 Vasuri F; Ciavarella C; Collura S; Mascoli C; Valente S; Degiovanni A; Gargiulo M; Capri M; Pasquinelli G Biomolecules 2021[Jul]; 11 (7): ä PMID34356687show ga We report the case of a 77-year-old woman affected by coronavirus disease-19 (COVID-19) who developed an occlusive arterial disease of the lower limb requiring a left leg amputation. We studied the mechanisms of vascular damage by SARS-CoV-2 by means of a comprehensive multi-technique in situ analysis on the diseased popliteal arterial district, including immunohistochemistry (IHC), transmission electron microscopy (TEM) and miRNA analysis. At histological analyses, we observed a lymphocytic inflammatory infiltrate, oedema and endothelialitis of adventitial vasa vasorum while the media was normal and the intima had only minor changes. The vasa vasorum expressed the ACE2 receptor and factor VIII; compared with the controls, VEGFR2 staining was reduced. TEM analyses showed endothelial injury and numerous Weibel-Palade bodies in the cytoplasm. No coronavirus particle was seen. IL-6 protein and mRNA, together with miR-155-5p and miRs-27a-5p, which can target IL-6, were significantly increased compared with that in the controls. Our case report suggests an involvement of adventitial artery microcirculation by inflammation in the course of COVID-19. Without evident signs of current infection by SARS-CoV-2, endothelial cells show a spectrum of structural and functional alterations that can fuel the cardiovascular complications observed in people infected with SARS-CoV-2. |Aged[MESH] |Arterial Occlusive Diseases/*etiology/pathology[MESH] |COVID-19/*complications/pathology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*etiology/pathology[MESH] |Leg/blood supply/pathology[MESH] |MicroRNAs/analysis[MESH] |Microcirculation[MESH]Adventitial Microcirculation Is a Major Target of SARS-CoV-2-Mediated (epmc).pdf DeepDyve Pubget Overpricing