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10.3389/fimmu.2021.708184

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.708184
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suck abstract from ncbi


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pmid34354712      Front+Immunol 2021 ; 12 (ä): 708184
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  • Dynamic Characteristic Analysis of Antibodies in Patients With COVID-19: A 13-Month Study #MMPMID34354712
  • Shi D; Weng T; Wu J; Dai C; Luo R; Chen K; Zhu M; Lu X; Cheng L; Chen Q; Liu F; Wu Z; Wu H; Jin C; Guo M; Chen Z; Wu N; Yao H; Zheng M
  • Front Immunol 2021[]; 12 (ä): 708184 PMID34354712show ga
  • There is a worldwide pandemic of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; yet our understanding remains limited on the characteristic of antibodies, especially for dynamic long-term tracking. Sequential serum samples were collected up to 416 days post onset of symptoms (POS) from 102 patients who were hospitalized with coronavirus disease 2019 (COVID-19). Immunoglobulin (Ig)G, IgM, and IgA levels targeting SARS-CoV-2 spike 1 receptor-binding domain (S1-RBD), spike 2 extracellular domain (S2-ECD), and nucleocapsid protein (N) were quantified as well as neutralizing activity. We were pleasantly surprised to find that the antibody remained detective and effective for more than a year POS. We also found the varied reactions of different antibodies as time passed: N-IgA rose most rapidly in the early stage of infection, while S2-IgG was present at a high level in the long time of observation. This study described the long traceable antibody response of the COVID-19 and offered hints about targets to screen for postinfectious immunity and for vaccination development of SARS-CoV-2.
  • |Aged[MESH]
  • |Antibodies, Neutralizing/*blood/immunology[MESH]
  • |Antibodies, Viral/*blood/immunology[MESH]
  • |COVID-19/diagnosis/*immunology[MESH]
  • |Coronavirus Nucleocapsid Proteins/immunology[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Isotypes/blood/immunology[MESH]
  • |Kinetics[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Models, Theoretical[MESH]
  • |Phosphoproteins/immunology[MESH]
  • |Protein Domains/immunology[MESH]
  • |SARS-CoV-2/*immunology/isolation & purification[MESH]
  • |Seroconversion[MESH]


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