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10.1038/s41419-021-04070-3 http://scihub22266oqcxt.onion/10.1038/s41419-021-04070-3 34354045!8340078!34354045     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2021 ; 12 (8): 773 Nephropedia Template TP {{tp|p=34354045|t=2021. Low level of plasminogen increases risk for mortality in COVID-19 patients |pdf=|usr=}}{{34354045}} gab.com Text Low level of plasminogen increases risk for mortality in COVID-19 patients JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=34354045 #FOAvip The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of plasminogen, as precursor of fibrinolysis, has been hypothesized. In this study, we aimed to investigate the association between plasminogen levels and COVID-19-related outcomes in a population of 55 infected Caucasian patients (mean age: 69.8 +/- 14.3, 41.8% female). Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidimensional analysis model, including the correlation of the expression of coagulation with inflammatory parameters, indicated that plasminogen tended to cluster together with IL-6, hence suggesting a common pathway of activation during disease's complication. Moreover, low levels of plasminogen strongly correlated with mortality in COVID-19 patients even after multiple adjustments for presence of confounding. These data suggest that plasminogen may play a pivotal role in controlling the complex mechanisms beyond the COVID-19 complications, and may be useful both as biomarker for prognosis and for therapeutic target against this extremely aggressive infection. Twit Text FOAVip Low level of plasminogen increases risk for mortality in COVID-19 patients ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=34354045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34354045 #FOAvip English Wikipedia <ref>{{Cite pmid|34354045}}</ref> Low level of plasminogen increases risk for mortality in COVID-19 patients #MMPMID34354045 Della-Morte D; Pacifici F; Ricordi C; Massoud R; Rovella V; Proietti S; Iozzo M; Lauro D; Bernardini S; Bonassi S; Di Daniele N Cell Death Dis 2021[Aug]; 12 (8): 773 PMID34354045show ga The pathophysiology of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and especially of its complications is still not fully understood. In fact, a very high number of patients with COVID-19 die because of thromboembolic causes. A role of plasminogen, as precursor of fibrinolysis, has been hypothesized. In this study, we aimed to investigate the association between plasminogen levels and COVID-19-related outcomes in a population of 55 infected Caucasian patients (mean age: 69.8 +/- 14.3, 41.8% female). Low levels of plasminogen were significantly associated with inflammatory markers (CRP, PCT, and IL-6), markers of coagulation (D-dimer, INR, and APTT), and markers of organ dysfunctions (high fasting blood glucose and decrease in the glomerular filtration rate). A multidimensional analysis model, including the correlation of the expression of coagulation with inflammatory parameters, indicated that plasminogen tended to cluster together with IL-6, hence suggesting a common pathway of activation during disease's complication. Moreover, low levels of plasminogen strongly correlated with mortality in COVID-19 patients even after multiple adjustments for presence of confounding. These data suggest that plasminogen may play a pivotal role in controlling the complex mechanisms beyond the COVID-19 complications, and may be useful both as biomarker for prognosis and for therapeutic target against this extremely aggressive infection. |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |Blood Coagulation[MESH] |COVID-19/*blood/diagnosis/*mortality[MESH] |Down-Regulation[MESH] |Female[MESH] |Humans[MESH] |Inflammation Mediators/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Plasminogen/*analysis[MESH] |Prognosis[MESH] |Risk Assessment[MESH] |Risk Factors[MESH]Low level of plasminogen increases risk for mortality in COVID-19 pati(epmc).pdf DeepDyve Pubget Overpricing