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suck abstract from ncbi


10.1186/s12941-021-00454-7

http://scihub22266oqcxt.onion/10.1186/s12941-021-00454-7
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suck abstract from ncbi


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pmid34353332      Ann+Clin+Microbiol+Antimicrob 2021 ; 20 (1): 51
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  • Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study #MMPMID34353332
  • Karatas M; Yasar-Duman M; Tunger A; Cilli F; Aydemir S; Ozenci V
  • Ann Clin Microbiol Antimicrob 2021[Aug]; 20 (1): 51 PMID34353332show ga
  • PURPOSE: In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era. METHODS: Microbiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data. RESULTS: In total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001). CONCLUSION: Due to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Anti-Bacterial Agents/pharmacology[MESH]
  • |Bacterial Infections/drug therapy/epidemiology/*microbiology[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19/epidemiology/*microbiology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Coinfection/epidemiology/*microbiology[MESH]
  • |Drug Resistance, Bacterial/*drug effects[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Male[MESH]
  • |Microbial Sensitivity Tests[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Turkey/epidemiology[MESH]


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