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suck abstract from ncbi


10.1186/s12887-021-02812-y

http://scihub22266oqcxt.onion/10.1186/s12887-021-02812-y
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34353302!8338201!34353302
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suck abstract from ncbi

pmid34353302      BMC+Pediatr 2021 ; 21 (1): 333
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  • New onset ANCA-associated vasculitis in an adolescent during an acute COVID-19 infection: a case report #MMPMID34353302
  • Reiff DD; Meyer CG; Marlin B; Mannion ML
  • BMC Pediatr 2021[Aug]; 21 (1): 333 PMID34353302show ga
  • BACKGROUND: SARS-CoV-2 has been found to be exquisitely adept at triggering autoimmunity and multiple new onset autoimmune diseases have been described as a post-infectious complication of COVID-19 infection in the adult population. Less has been described in the pediatric population, as infections are more likely to be asymptomatic and less severe. This case reports a previously healthy adolescent patient with new onset antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) diagnosed in the setting of acute COVID-19 infection. CASE PRESENTATION: A previously healthy adolescent male was diagnosed with COVID-19 pneumonia after presenting with infectious symptoms of fever, cough, congestion, and shortness of breath. After worsening of disease, he was found to have pulmonary nodules, atypical for COVID-19. Further imaging and laboratory workup showed elevated inflammatory markers, negative infectious testing, and positive antineutrophil cytoplasmic antibodies (ANCA) diagnostic for AAV. He was treated with pulse dose steroids followed by a prolonged taper and rituximab. Symptoms resolved and laboratory abnormalities improved over time. At six-month follow-up, lesions were much improved, laboratory markers were within normal limits, and patient remained asymptomatic off medications. CONCLUSIONS: This case is one of the first in the pediatric population to describe new onset AAV presenting with an acute, symptomatic COVID-19 infection. There is increasing evidence for COVID-19 induced autoimmunity in the pediatric population and pediatric care providers should be on high alert for new onset autoimmune disease in children afflicted by COVID-19.
  • |*Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications/diagnosis/drug therapy[MESH]
  • |*COVID-19[MESH]
  • |*Infections[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antibodies, Antineutrophil Cytoplasmic[MESH]
  • |Child[MESH]
  • |Humans[MESH]
  • |Male[MESH]


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