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10.1002/cmdc.202100476 http://scihub22266oqcxt.onion/10.1002/cmdc.202100476 34352160!8426689!34352160     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34352160&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       ChemMedChem 2021 ; 16 (22): 3418-3427 Nephropedia Template TP {{tp|p=34352160|t=2021. New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS-CoV-2 |pdf=|usr=}}{{34352160}} gab.com Text New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS-CoV-2 JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=34352160 #FOAvip Currently, limited therapeutic options are available for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We have developed a set of pyrazine-based small molecules. A series of pyrazine conjugates was synthesized by microwave-assisted click chemistry and benzotriazole chemistry. All the synthesized conjugates were screened against the SAR-CoV-2 virus and their cytotoxicity was determined. Computational studies were carried out to validate the biological data. Some of the pyrazine-triazole conjugates (5 d-g) and (S)-N-(1-(benzo[d]thiazol-2-yl)-2-phenylethyl)pyrazine-2-carboxamide 12 i show significant potency against SARS-CoV-2 among the synthesized conjugates. The selectivity index (SI) of potent conjugates indicates significant efficacy compared to the reference drug (Favipiravir). Twit Text FOAVip New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS-CoV-2 ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=34352160 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34352160 #FOAvip English Wikipedia <ref>{{Cite pmid|34352160}}</ref> New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS-CoV-2 #MMPMID34352160 Seliem IA; Girgis AS; Moatasim Y; Kandeil A; Mostafa A; Ali MA; Bekheit MS; Panda SS ChemMedChem 2021[Nov]; 16 (22): 3418-3427 PMID34352160show ga Currently, limited therapeutic options are available for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We have developed a set of pyrazine-based small molecules. A series of pyrazine conjugates was synthesized by microwave-assisted click chemistry and benzotriazole chemistry. All the synthesized conjugates were screened against the SAR-CoV-2 virus and their cytotoxicity was determined. Computational studies were carried out to validate the biological data. Some of the pyrazine-triazole conjugates (5 d-g) and (S)-N-(1-(benzo[d]thiazol-2-yl)-2-phenylethyl)pyrazine-2-carboxamide 12 i show significant potency against SARS-CoV-2 among the synthesized conjugates. The selectivity index (SI) of potent conjugates indicates significant efficacy compared to the reference drug (Favipiravir). |Amides/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/chemical synthesis/metabolism/*pharmacology/toxicity[MESH] |Chlorocebus aethiops[MESH] |Coronavirus RNA-Dependent RNA Polymerase/metabolism[MESH] |Microbial Sensitivity Tests[MESH] |Molecular Docking Simulation[MESH] |Molecular Structure[MESH] |Pyrazines/chemical synthesis/metabolism/*pharmacology/toxicity[MESH] |Quantitative Structure-Activity Relationship[MESH] |SARS-CoV-2/*drug effects[MESH]New Pyrazine Conjugates: Synthesis, Computational Studies, and Antivir(epmc).pdf DeepDyve Pubget Overpricing