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10.1111/jvh.13590

http://scihub22266oqcxt.onion/10.1111/jvh.13590
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34352133!8446947!34352133
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suck abstract from ncbi


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pmid34352133      J+Viral+Hepat 2022 ; 29 (1): 4-20
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  • COVID-19 and the Liver: Lessons Learnt from the EAST and the WEST, A Year Later #MMPMID34352133
  • Ekpanyapong S; Bunchorntavakul C; Reddy KR
  • J Viral Hepat 2022[Jan]; 29 (1): 4-20 PMID34352133show ga
  • Globally, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 virus) has been a major cause for significant morbidity and mortality. Since the start of the pandemic, several hepato-biliary manifestations in coronavirus disease 2019 (COVID-19) have been described and unique considerations raised. The review aims to summarize the pathogenesis and hepato-biliary manifestations in COVID-19 and discuss the similarities, contrasting features and disease-specific management across a range of hepato-biliary diseases from the EAST and the WEST. Published studies and regional society guidelines from the EAST and the WEST were comprehensively reviewed and summarized. A wide range of hepato-biliary manifestations, including the infrequent and chronic manifestation of cholangiopathy, has been observed in COVID-19. The pathogenesis of liver injury is multifactorial and with scant evidence for a direct SARS-CoV-2 infection of the liver. Patients with non-alcoholic fatty liver disease, cirrhosis, and liver cancer are potentially at increased risk for severe COVID-19, and there are unique considerations in chronic hepatitis B or C, hepatocellular carcinoma, and in those immunosuppressed such as autoimmune hepatitis or liver transplant recipients. With the surges in SARS-CoV-2 infection, liver transplant activity has variably been impacted. Preliminarily, SARS-CoV-2 vaccines appear to be safe in those with chronic liver disease and in transplant recipients, while emerging data suggest the need for a third dose in immunosuppressed patients. In conclusion, patients with chronic liver disease, particularly cirrhosis, and liver transplant recipients, are vulnerable to severe COVID-19. Over the past year, several unique considerations have been highlighted across a spectrum of hepato-biliary diseases. Vaccination is strongly recommended for those with chronic liver disease and liver transplant recipients.
  • |*COVID-19[MESH]
  • |*Liver Diseases/epidemiology[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Humans[MESH]


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