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10.1126/sciadv.abg7181 http://scihub22266oqcxt.onion/10.1126/sciadv.abg7181 34348897!8336950!34348897     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34348897&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Adv 2021 ; 7 (32): ä Nephropedia Template TP {{tp|p=34348897|t=2021. Effect of BCG vaccination on proinflammatory responses in elderly individuals |pdf=|usr=}}{{34348897}} gab.com Text Effect of BCG vaccination on proinflammatory responses in elderly individuals JO: Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34348897 #FOAvip We investigated the influence of Bacillus Calmette-Guerin (BCG) vaccination on the unstimulated plasma levels of a wide panel of cytokines, chemokines, acute-phase proteins (APPs), matrix metalloproteinases (MMPs), and growth factors in a group of healthy elderly individuals (age, 60 to 80 years) at baseline (before vaccination) and 1 month after vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrated that BCG vaccination resulted in diminished plasma levels of types 1, 2, and 17 and other proinflammatory cytokines and type 1 interferons. BCG vaccination also resulted in decreased plasma levels of CC, CXC chemokines, APPs, MMPs, and growth factors. Plasma levels of the aforementioned parameters were significantly lower in vaccinated individuals when compared to unvaccinated control individuals. Thus, our study demonstrates the immunomodulatory properties of BCG vaccination and suggests its potential utility in nonspecific vaccination of COVID-19 by down-modulating pathogenic inflammatory responses. Twit Text FOAVip Effect of BCG vaccination on proinflammatory responses in elderly individuals ????Sci Adv http://www.kidney.de/pget.php?&tw=1&pmid=34348897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34348897 #FOAvip English Wikipedia <ref>{{Cite pmid|34348897}}</ref> Effect of BCG vaccination on proinflammatory responses in elderly individuals #MMPMID34348897 Pavan Kumar N; Padmapriyadarsini C; Rajamanickam A; Marinaik SB; Nancy A; Padmanaban S; Akbar N; Murhekar M; Babu S Sci Adv 2021[Aug]; 7 (32): ä PMID34348897show ga We investigated the influence of Bacillus Calmette-Guerin (BCG) vaccination on the unstimulated plasma levels of a wide panel of cytokines, chemokines, acute-phase proteins (APPs), matrix metalloproteinases (MMPs), and growth factors in a group of healthy elderly individuals (age, 60 to 80 years) at baseline (before vaccination) and 1 month after vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrated that BCG vaccination resulted in diminished plasma levels of types 1, 2, and 17 and other proinflammatory cytokines and type 1 interferons. BCG vaccination also resulted in decreased plasma levels of CC, CXC chemokines, APPs, MMPs, and growth factors. Plasma levels of the aforementioned parameters were significantly lower in vaccinated individuals when compared to unvaccinated control individuals. Thus, our study demonstrates the immunomodulatory properties of BCG vaccination and suggests its potential utility in nonspecific vaccination of COVID-19 by down-modulating pathogenic inflammatory responses. |Aged[MESH] |Aged, 80 and over[MESH] |BCG Vaccine/*administration & dosage/immunology[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Case-Control Studies[MESH] |Cytokines/*metabolism[MESH] |Female[MESH] |Humans[MESH] |India/epidemiology[MESH] |Inflammation Mediators/*metabolism[MESH] |Inflammation/immunology/metabolism/pathology/*prevention & control[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/immunology[MESH]Effect of BCG vaccination on proinflammatory responses in elderly indi(epmc).pdf DeepDyve Pubget Overpricing