The COVIDome Explorer researcher portal #MMPMID34348131
Sullivan KD; Galbraith MD; Kinning KT; Bartsch KW; Levinsky NC; Araya P; Smith KP; Granrath RE; Shaw JR; Baxter RM; Jordan KR; Russell SA; Dzieciatkowska ME; Reisz JA; Gamboni F; Cendali FI; Ghosh T; Monte AA; Bennett TD; Miller MG; Hsieh EW; D'Alessandro A; Hansen KC; Espinosa JM
Cell Rep 2021[Aug]; 36 (7): 109527 PMID34348131show ga
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients, including matched analysis of the whole-blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, plasma and red blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and clinical data annotation. We refer to this multidimensional dataset as the COVIDome. We then created the COVIDome Explorer, an online researcher portal where the data can be analyzed and visualized in real time. We illustrate herein the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patterns, depletion of protective serpins, and mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer will rapidly accelerate data sharing, hypothesis testing, and discoveries worldwide.
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Cell+Rep 2021 ; 36 (7): 109527
