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10.1371/journal.pone.0255335 http://scihub22266oqcxt.onion/10.1371/journal.pone.0255335 34347801!8336874!34347801     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2021 ; 16 (8): e0255335 Nephropedia Template TP {{tp|p=34347801|t=2021. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease |pdf=|usr=}}{{34347801}} gab.com Text Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34347801 #FOAvip The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses. Twit Text FOAVip Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=34347801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34347801 #FOAvip English Wikipedia <ref>{{Cite pmid|34347801}}</ref> Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease #MMPMID34347801 Ricke-Hoch M; Stelling E; Lasswitz L; Gunesch AP; Kasten M; Zapatero-Belinchon FJ; Brogden G; Gerold G; Pietschmann T; Montiel V; Balligand JL; Facciotti F; Hirsch E; Gausepohl T; Elbahesh H; Rimmelzwaan GF; Hofer A; Kuhnel MP; Jonigk D; Eigendorf J; Tegtbur U; Mink L; Scherr M; Illig T; Schambach A; Pfeffer TJ; Hilfiker A; Haverich A; Hilfiker-Kleiner D PLoS One 2021[]; 16 (8): e0255335 PMID34347801show ga The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from unaffected subjects. In COVID-19 patients, PGE2 blood levels are markedly elevated and correlate positively with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hydroxyprostaglandin-dehydrogenase. Also living human precision cut lung slices (PCLS) infected with SARS-CoV-2 display upregulated COX-2. Regular exercise in aged individuals lowers PGE2 serum levels, which leads to increased Paired-Box-Protein-Pax-5 (PAX5) expression, a master regulator of B-cell survival, proliferation and differentiation also towards long lived memory B-cells, in human pre-B-cell lines. Moreover, PGE2 levels in serum of COVID-19 patients lowers the expression of PAX5 in human pre-B-cell lines. The PGE2 inhibitor Taxifolin reduces SARS-CoV-2-induced PGE2 production. In conclusion, SARS-CoV-2, male sex, old age, and sedentary life style increase PGE2 levels, which may reduce the early anti-viral defense as well as the development of immunity promoting severe disease courses and multiple infections. Regular exercise and Taxifolin treatment may reduce these risks and prevent severe disease courses. |*Immunity/drug effects/physiology[MESH] |Adolescent[MESH] |Adult[MESH] |Animals[MESH] |COVID-19/blood/immunology/*pathology[MESH] |Case-Control Studies[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Dinoprostone/*blood/pharmacology/physiology[MESH] |Disease Progression[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/drug effects/physiology[MESH] |Vero Cells[MESH]Impaired immune response mediated by prostaglandin E2 promotes severe (epmc).pdf DeepDyve Pubget Overpricing