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10.1016/j.clim.2021.108814

http://scihub22266oqcxt.onion/10.1016/j.clim.2021.108814
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34343708!8325385!34343708
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suck abstract from ncbi


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pmid34343708      Clin+Immunol 2021 ; 230 (ä): 108814
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  • Longitudinal observation of antibody responses for 14 months after SARS-CoV-2 infection #MMPMID34343708
  • Dehgani-Mobaraki P; Zaidi AK; Yadav N; Floridi A; Floridi E
  • Clin Immunol 2021[Sep]; 230 (ä): 108814 PMID34343708show ga
  • Better understanding of antibody responses against SARS-CoV-2 after natural infection might provide valuable insights into the future implementation of vaccination policies. Longitudinal analysis of IgG antibody titers was carried out in 32 recovered COVID-19 patients based in the Umbria region of Italy for 14 months after Mild and Moderately-Severe infection.Two FDA-approved immunoassays against SARS-CoV-2 Nucleocapsid protein (NCP) and anti-spike-receptor binding domain (S-RBD) were used for sequential serological tests at different time points. The demographics,clinical history and symptom profile associated with the magnitude and longevity of antibody responses were also analyzed. Anti-S-RBD IgG persisted in 96.8% (31 of 32) subjects at 14 months. Patients reporting loss of smell and taste during the clinical course of the disease developed significantly higher antibody titers. Anti-NCP IgG seronegative patients(n=7) at 10 months, tested positive for anti-S-RBD IgG at 12,13 and 14 months emphasizing on a higher false-negative rate for NCP protein-based antibody assays. This study also highlights the importance of adopting specific immunoassays for routine estimation of antibody titers and the decreased rate of re-infections in recovered patients.
  • |Adult[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19 Vaccines/administration & dosage/*immunology[MESH]
  • |COVID-19/blood/*immunology/prevention & control/*virology[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/*blood[MESH]
  • |Immunoglobulin M/blood[MESH]
  • |Longitudinal Studies[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pilot Projects[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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