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10.7554/eLife.71047 http://scihub22266oqcxt.onion/10.7554/eLife.71047 34342578!8357416!34342578     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2021 ; 10 (ä): ä Nephropedia Template TP {{tp|p=34342578|t=2021. Endomembrane targeting of human OAS1 p46 augments antiviral activity |pdf=|usr=}}{{34342578}} gab.com Text Endomembrane targeting of human OAS1 p46 augments antiviral activity JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=34342578 #FOAvip Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from cellular innate immune sensors. Targeting innate RNA sensors to the endomembrane system may enhance their ability to sense RNA generated by viruses that use these compartments for replication. Here, we reveal that an isoform of oligoadenylate synthetase 1, OAS1 p46, is prenylated and targeted to the endomembrane system. Membrane localization of OAS1 p46 confers enhanced access to viral replication sites and results in increased antiviral activity against a subset of RNA viruses including flaviviruses, picornaviruses, and SARS-CoV-2. Finally, our human genetic analysis shows that the OAS1 splice-site SNP responsible for production of the OAS1 p46 isoform correlates with protection from severe COVID-19. This study highlights the importance of endomembrane targeting for the antiviral specificity of OAS1 and suggests that early control of SARS-CoV-2 replication through OAS1 p46 is an important determinant of COVID-19 severity. Twit Text FOAVip Endomembrane targeting of human OAS1 p46 augments antiviral activity ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=34342578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34342578 #FOAvip English Wikipedia <ref>{{Cite pmid|34342578}}</ref> Endomembrane targeting of human OAS1 p46 augments antiviral activity #MMPMID34342578 Soveg FW; Schwerk J; Gokhale NS; Cerosaletti K; Smith JR; Pairo-Castineira E; Kell AM; Forero A; Zaver SA; Esser-Nobis K; Roby JA; Hsiang TY; Ozarkar S; Clingan JM; McAnarney ET; Stone AE; Malhotra U; Speake C; Perez J; Balu C; Allenspach EJ; Hyde JL; Menachery VD; Sarkar SN; Woodward JJ; Stetson DB; Baillie JK; Buckner JH; Gale M Jr; Savan R Elife 2021[Aug]; 10 (ä): ä PMID34342578show ga Many host RNA sensors are positioned in the cytosol to detect viral RNA during infection. However, most positive-strand RNA viruses replicate within a modified organelle co-opted from intracellular membranes of the endomembrane system, which shields viral products from cellular innate immune sensors. Targeting innate RNA sensors to the endomembrane system may enhance their ability to sense RNA generated by viruses that use these compartments for replication. Here, we reveal that an isoform of oligoadenylate synthetase 1, OAS1 p46, is prenylated and targeted to the endomembrane system. Membrane localization of OAS1 p46 confers enhanced access to viral replication sites and results in increased antiviral activity against a subset of RNA viruses including flaviviruses, picornaviruses, and SARS-CoV-2. Finally, our human genetic analysis shows that the OAS1 splice-site SNP responsible for production of the OAS1 p46 isoform correlates with protection from severe COVID-19. This study highlights the importance of endomembrane targeting for the antiviral specificity of OAS1 and suggests that early control of SARS-CoV-2 replication through OAS1 p46 is an important determinant of COVID-19 severity. |2',5'-Oligoadenylate Synthetase/*metabolism[MESH] |Animals[MESH] |COVID-19/immunology/*virology[MESH] |CRISPR-Cas Systems[MESH] |Cell Line[MESH] |Gene Editing[MESH] |Humans[MESH] |Polymorphism, Single Nucleotide[MESH]Endomembrane targeting of human OAS1 p46 augments antiviral activity (epmc).pdf DeepDyve Pubget Overpricing