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  • SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation #MMPMID34341353
  • Pan P; Shen M; Yu Z; Ge W; Chen K; Tian M; Xiao F; Wang Z; Wang J; Jia Y; Wang W; Wan P; Zhang J; Chen W; Lei Z; Chen X; Luo Z; Zhang Q; Xu M; Li G; Li Y; Wu J
  • Nat Commun 2021[Aug]; 12 (1): 4664 PMID34341353show ga
  • Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. N protein facilitates maturation of proinflammatory cytokines and induces proinflammatory responses in cultured cells and mice. Mechanistically, N protein interacts directly with NLRP3 protein, promotes the binding of NLRP3 with ASC, and facilitates NLRP3 inflammasome assembly. More importantly, N protein aggravates lung injury, accelerates death in sepsis and acute inflammation mouse models, and promotes IL-1beta and IL-6 activation in mice. Notably, N-induced lung injury and cytokine production are blocked by MCC950 (a specific inhibitor of NLRP3) and Ac-YVAD-cmk (an inhibitor of caspase-1). Therefore, this study reveals a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation and induces excessive inflammatory responses.
  • |Animals[MESH]
  • |COVID-19/*metabolism/virology[MESH]
  • |Cells, Cultured[MESH]
  • |Coronavirus Nucleocapsid Proteins/*metabolism[MESH]
  • |Cytokines/metabolism[MESH]
  • |HEK293 Cells[MESH]
  • |Humans[MESH]
  • |Inflammasomes/genetics/*metabolism[MESH]
  • |Inflammation/*metabolism[MESH]
  • |Lung Injury/genetics/metabolism[MESH]
  • |Male[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Mice, Knockout[MESH]
  • |NLR Family, Pyrin Domain-Containing 3 Protein/genetics/*metabolism[MESH]
  • |Phosphoproteins/metabolism[MESH]
  • |Protein Binding[MESH]
  • |SARS-CoV-2/*metabolism/physiology[MESH]
  • |THP-1 Cells[MESH]

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  • suck abstract from ncbi

    4664 1.12 2021