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10.1038/s41467-021-25015-6 http://scihub22266oqcxt.onion/10.1038/s41467-021-25015-6 34341353!8329225!34341353     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4664 Nephropedia Template TP {{tp|p=34341353|t=2021. SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation |pdf=|usr=}}{{34341353}} gab.com Text SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34341353 #FOAvip Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. N protein facilitates maturation of proinflammatory cytokines and induces proinflammatory responses in cultured cells and mice. Mechanistically, N protein interacts directly with NLRP3 protein, promotes the binding of NLRP3 with ASC, and facilitates NLRP3 inflammasome assembly. More importantly, N protein aggravates lung injury, accelerates death in sepsis and acute inflammation mouse models, and promotes IL-1beta and IL-6 activation in mice. Notably, N-induced lung injury and cytokine production are blocked by MCC950 (a specific inhibitor of NLRP3) and Ac-YVAD-cmk (an inhibitor of caspase-1). Therefore, this study reveals a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation and induces excessive inflammatory responses. Twit Text FOAVip SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34341353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34341353 #FOAvip English Wikipedia <ref>{{Cite pmid|34341353}}</ref> SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation #MMPMID34341353 Pan P; Shen M; Yu Z; Ge W; Chen K; Tian M; Xiao F; Wang Z; Wang J; Jia Y; Wang W; Wan P; Zhang J; Chen W; Lei Z; Chen X; Luo Z; Zhang Q; Xu M; Li G; Li Y; Wu J Nat Commun 2021[Aug]; 12 (1): 4664 PMID34341353show ga Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. N protein facilitates maturation of proinflammatory cytokines and induces proinflammatory responses in cultured cells and mice. Mechanistically, N protein interacts directly with NLRP3 protein, promotes the binding of NLRP3 with ASC, and facilitates NLRP3 inflammasome assembly. More importantly, N protein aggravates lung injury, accelerates death in sepsis and acute inflammation mouse models, and promotes IL-1beta and IL-6 activation in mice. Notably, N-induced lung injury and cytokine production are blocked by MCC950 (a specific inhibitor of NLRP3) and Ac-YVAD-cmk (an inhibitor of caspase-1). Therefore, this study reveals a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3 inflammasome activation and induces excessive inflammatory responses. |Animals[MESH] |COVID-19/*metabolism/virology[MESH] |Cells, Cultured[MESH] |Coronavirus Nucleocapsid Proteins/*metabolism[MESH] |Cytokines/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Inflammasomes/genetics/*metabolism[MESH] |Inflammation/*metabolism[MESH] |Lung Injury/genetics/metabolism[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Knockout[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/genetics/*metabolism[MESH] |Phosphoproteins/metabolism[MESH] |Protein Binding[MESH] |SARS-CoV-2/*metabolism/physiology[MESH]SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce (epmc).pdf DeepDyve Pubget Overpricing