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10.1021/acsinfecdis.1c00253 http://scihub22266oqcxt.onion/10.1021/acsinfecdis.1c00253 34339171!ä!34339171 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34339171&cmd=llinks): Failed to open stream: HTTP request failed! 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Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model |pdf=|usr=}}{{34339171}} gab.com Text Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model JO: ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34339171 #FOAvip SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highly contagious, to dying from acute respiratory distress syndrome. Although the world has mobilized to create antiviral vaccines and therapeutics to combat the scourge, their long-term efficacy remains in question especially with the emergence of new variants. In this work, we exploit a class of compounds that has previously shown success against various viruses. A salicylanilide library was first screened in a SARS-CoV-2 activity assay in Vero cells. The most efficacious derivative was further evaluated in a prophylactic mouse model of SARS-CoV-2 infection unveiling a salicylanilide that can reduce viral loads, modulate key cytokines, and mitigate severe weight loss involved in COVID-19 infections. The combination of anti-SARS-CoV-2 activity, cytokine inhibitory activity, and a previously established favorable pharmacokinetic profile for the lead salicylanilide renders salicylanilides in general as promising therapeutics for COVID-19. Twit Text FOAVip Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model ????ACS Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=34339171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34339171 #FOAvip English Wikipedia <ref>{{Cite pmid|34339171}}</ref> Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction of Inflammatory Cytokines in a Rodent Model #MMPMID34339171 Blake S; Shaabani N; Eubanks LM; Maruyama J; Manning JT; Beutler N; Paessler S; Ji H; Teijaro JR; Janda KD ACS Infect Dis 2021[Aug]; 7 (8): 2229-2237 PMID34339171show ga SARS-CoV-2 virus has recently given rise to the current COVID-19 pandemic where infected individuals can range from being asymptomatic, yet highly contagious, to dying from acute respiratory distress syndrome. Although the world has mobilized to create antiviral vaccines and therapeutics to combat the scourge, their long-term efficacy remains in question especially with the emergence of new variants. In this work, we exploit a class of compounds that has previously shown success against various viruses. A salicylanilide library was first screened in a SARS-CoV-2 activity assay in Vero cells. The most efficacious derivative was further evaluated in a prophylactic mouse model of SARS-CoV-2 infection unveiling a salicylanilide that can reduce viral loads, modulate key cytokines, and mitigate severe weight loss involved in COVID-19 infections. The combination of anti-SARS-CoV-2 activity, cytokine inhibitory activity, and a previously established favorable pharmacokinetic profile for the lead salicylanilide renders salicylanilides in general as promising therapeutics for COVID-19. |*COVID-19[MESH] |*Pandemics[MESH] |Animals[MESH] |Chlorocebus aethiops[MESH] |Cytokines[MESH] |Humans[MESH] |Mice[MESH] |Rodentia[MESH] |SARS-CoV-2[MESH] |Salicylanilides[MESH]Salicylanilides Reduce SARS-CoV-2 Replication and Suppress Induction o(epmc).pdf DeepDyve Pubget Overpricing