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10.1042/CS20210284 http://scihub22266oqcxt.onion/10.1042/CS20210284 34338772!8329853!34338772     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2021 ; 135 (15): 1805-1824 Nephropedia Template TP {{tp|p=34338772|t=2021. Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility |pdf=|usr=}}{{34338772}} gab.com Text Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=34338772 #FOAvip In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manifestation, particularly in the placenta and/or feto-maternal circulation. Beyond the risk of vertical transmission, COVID-19 is also proposed to deplete ACE2 protein and its biological actions in the placenta. It is postulated that such effects may impair essential processes during placentation and maternal hemodynamic adaptations in COVID-19 pregnancy, features also observed in several disorders of pregnancy. This review gathers information indicating risks and protective features related to ACE2 changes in COVID-19 pregnancies. First, we describe the mechanisms of SARS-CoV-2 infection having ACE2 as a main entry door and current evidence of viral infection in the placenta. Further, we discuss the central role of ACE2 in physiological systems such as the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), both active during placentation and hemodynamic adaptations of pregnancy. Significant knowledge gaps are also identified and should be urgently filled to better understand the fate of ACE2 in COVID-19 pregnancies and the potential associated risks. Emerging knowledge will be able to improve the early stratification of high-risk pregnancies with COVID-19 exposure as well as to guide better management and follow-up of these mothers and their children. Twit Text FOAVip Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=34338772 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34338772 #FOAvip English Wikipedia <ref>{{Cite pmid|34338772}}</ref> Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility #MMPMID34338772 Azinheira Nobrega Cruz N; Stoll D; Casarini DE; Bertagnolli M Clin Sci (Lond) 2021[Aug]; 135 (15): 1805-1824 PMID34338772show ga In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence of angiotensin-converting enzyme (ACE) 2 (ACE2), the main receptor for SARS-CoV-2, in human placentas indicates that this organ can be vulnerable for viral infection during pregnancy. However, for this to happen, additional molecular processes are critical to allow viral entry in cells, its replication and disease manifestation, particularly in the placenta and/or feto-maternal circulation. Beyond the risk of vertical transmission, COVID-19 is also proposed to deplete ACE2 protein and its biological actions in the placenta. It is postulated that such effects may impair essential processes during placentation and maternal hemodynamic adaptations in COVID-19 pregnancy, features also observed in several disorders of pregnancy. This review gathers information indicating risks and protective features related to ACE2 changes in COVID-19 pregnancies. First, we describe the mechanisms of SARS-CoV-2 infection having ACE2 as a main entry door and current evidence of viral infection in the placenta. Further, we discuss the central role of ACE2 in physiological systems such as the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), both active during placentation and hemodynamic adaptations of pregnancy. Significant knowledge gaps are also identified and should be urgently filled to better understand the fate of ACE2 in COVID-19 pregnancies and the potential associated risks. Emerging knowledge will be able to improve the early stratification of high-risk pregnancies with COVID-19 exposure as well as to guide better management and follow-up of these mothers and their children. |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Biomarkers/metabolism[MESH] |COVID-19/*metabolism/transmission/virology[MESH] |Female[MESH] |Humans[MESH] |Infectious Disease Transmission, Vertical[MESH] |Placenta/metabolism/*virology[MESH] |Pregnancy[MESH] |Pregnancy Complications, Infectious/*metabolism/virology[MESH] |Receptors, Coronavirus/*metabolism[MESH] |Risk Factors[MESH] |SARS-CoV-2/*pathogenicity[MESH]Role of ACE2 in pregnancy and potential implications for COVID-19 susc(epmc).pdf DeepDyve Pubget Overpricing