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10.7150/thno.61832

http://scihub22266oqcxt.onion/10.7150/thno.61832
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34335977!8315065!34335977
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suck abstract from ncbi


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pmid34335977      Theranostics 2021 ; 11 (16): 8008-8026
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  • Multi-omic profiling of plasma reveals molecular alterations in children with COVID-19 #MMPMID34335977
  • Wang C; Li X; Ning W; Gong S; Yang F; Fang C; Gong Y; Wu D; Huang M; Gou Y; Fu S; Ren Y; Yang R; Qiu Y; Xue Y; Xu Y; Zhou X
  • Theranostics 2021[]; 11 (16): 8008-8026 PMID34335977show ga
  • Rationale: Children usually develop less severe symptoms responding to Coronavirus Disease 2019 (COVID-19) than adults. However, little is known about the molecular alterations and pathogenesis of COVID-19 in children. Methods: We conducted plasma proteomic and metabolomic profilings of the blood samples of a cohort containing 18 COVID-19-children with mild symptoms and 12 healthy children, which were enrolled from hospital admissions and outpatients, respectively. Statistical analyses were performed to identify molecules specifically altered in COVID-19-children. We also developed a machine learning-based pipeline named inference of biomolecular combinations with minimal bias (iBM) to prioritize proteins and metabolites strongly altered in COVID-19-children, and experimentally validated the predictions. Results: By comparing to the multi-omic data in adults, we identified 44 proteins and 249 metabolites differentially altered in COVID-19-children against healthy children or COVID-19-adults. Further analyses demonstrated that both deteriorative immune response/inflammation processes and protective antioxidant or anti-inflammatory processes were markedly induced in COVID-19-children. Using iBM, we prioritized two combinations that contained 5 proteins and 5 metabolites, respectively, each exhibiting a total area under curve (AUC) value of 100% to accurately distinguish COVID-19-children from healthy children or COVID-19-adults. Further experiments validated that all the 5 proteins were up-regulated upon coronavirus infection. Interestingly, we found that the prioritized metabolites inhibited the expression of pro-inflammatory factors, and two of them, methylmalonic acid (MMA) and mannitol, also suppressed coronaviral replication, implying a protective role of these metabolites in COVID-19-children. Conclusion: The finding of a strong antagonism of deteriorative and protective effects provided new insights on the mechanism and pathogenesis of COVID-19 in children that mostly underwent mild symptoms. The identified metabolites strongly altered in COVID-19-children could serve as potential therapeutic agents of COVID-19.
  • |Adult[MESH]
  • |COVID-19/*blood/epidemiology/immunology/*virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |China/epidemiology[MESH]
  • |Female[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Metabolomics/methods[MESH]
  • |Middle Aged[MESH]
  • |Proteomics/methods[MESH]


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