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10.1016/j.diabet.2021.101268 http://scihub22266oqcxt.onion/10.1016/j.diabet.2021.101268 34333093!8320244!34333093     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34333093.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes+Metab 2021 ; 47 (6): 101268 Nephropedia Template TP {{tp|p=34333093|t=2021. Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19 |pdf=|usr=}}{{34333093}} gab.com Text Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19 JO: Diabetes Metab http://www.kidney.de/pget.php?&tw=1&pmid=34333093 #FOAvip AIM: Obesity is a risk factor for COVID-19, but the underlying mechanisms are unclear. We investigated the role of adiponectin (an anti-inflammatory adipokine), leptin (a pro-inflammatory adipokine) and their ratio (Adpn/Lep) in this context. DESIGN: Single-centre, prospective observational study. METHODS: Adiponectin and leptin were measured in 60 COVID-19 patients with mild (not hospitalised, n=11), moderate (hospitalised but not requiring intensive care, n=25) and severe (admission to the intensive care unit [ICU] or death, n=24) disease. RESULTS: Adiponectin and leptin levels were similar across severity groups, but patients with moderate severity had the highest Adpn/Lep ratio (1.2 [0.5; 2.0], 5.0 [1.6; 11.2], 2.1 [1.0; 3.6] in mild, moderate and severe disease; P = 0.019). Adpn/Lep, but not adiponectin or leptin alone, correlated with systemic inflammation (C reactive protein, CRP: Spearman's rho 0.293, P = 0.023). When dividing patients into Adpn/Lep tertiles, adiponectin was highest, whereas leptin was lowest in the third (highest) tertile. Patients in the highest Adpn/Lep tertile had numerically lower rates of obesity, diabetes and hypertension, and lower rates of death or admission to ICU versus other tertiles. At linear regression in the whole cohort, CRP significantly predicted Adpn/Lep (beta 0.291, P = 0.022), while female gender (beta -0.289, P = 0.016), diabetes (beta -0.257, P = 0.028), and hypertension (beta -239, P = 0.043) were negative predictors. CONCLUSIONS: We speculate that the rise in Adpn/Lep, due to increased adiponectin and reduced leptin, is a compensatory response to systemic inflammation. In patients with worse cardiometabolic health (e.g. diabetes, hypertension) this mechanism might be blunted, possibly contributing to higher mortality. Twit Text FOAVip Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19 ????Diabetes Metab http://www.kidney.de/pget.php?&tw=1&pmid=34333093 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34333093 #FOAvip English Wikipedia <ref>{{Cite pmid|34333093}}</ref> Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19 #MMPMID34333093 Di Filippo L; De Lorenzo R; Sciorati C; Capobianco A; Lore NI; Giustina A; Manfredi AA; Rovere-Querini P; Conte C Diabetes Metab 2021[Nov]; 47 (6): 101268 PMID34333093show ga AIM: Obesity is a risk factor for COVID-19, but the underlying mechanisms are unclear. We investigated the role of adiponectin (an anti-inflammatory adipokine), leptin (a pro-inflammatory adipokine) and their ratio (Adpn/Lep) in this context. DESIGN: Single-centre, prospective observational study. METHODS: Adiponectin and leptin were measured in 60 COVID-19 patients with mild (not hospitalised, n=11), moderate (hospitalised but not requiring intensive care, n=25) and severe (admission to the intensive care unit [ICU] or death, n=24) disease. RESULTS: Adiponectin and leptin levels were similar across severity groups, but patients with moderate severity had the highest Adpn/Lep ratio (1.2 [0.5; 2.0], 5.0 [1.6; 11.2], 2.1 [1.0; 3.6] in mild, moderate and severe disease; P = 0.019). Adpn/Lep, but not adiponectin or leptin alone, correlated with systemic inflammation (C reactive protein, CRP: Spearman's rho 0.293, P = 0.023). When dividing patients into Adpn/Lep tertiles, adiponectin was highest, whereas leptin was lowest in the third (highest) tertile. Patients in the highest Adpn/Lep tertile had numerically lower rates of obesity, diabetes and hypertension, and lower rates of death or admission to ICU versus other tertiles. At linear regression in the whole cohort, CRP significantly predicted Adpn/Lep (beta 0.291, P = 0.022), while female gender (beta -0.289, P = 0.016), diabetes (beta -0.257, P = 0.028), and hypertension (beta -239, P = 0.043) were negative predictors. CONCLUSIONS: We speculate that the rise in Adpn/Lep, due to increased adiponectin and reduced leptin, is a compensatory response to systemic inflammation. In patients with worse cardiometabolic health (e.g. diabetes, hypertension) this mechanism might be blunted, possibly contributing to higher mortality. |*Adiponectin/blood[MESH] |*COVID-19/mortality/therapy[MESH] |*Leptin/blood[MESH] |Female[MESH] |Humans[MESH] |Inflammation/blood[MESH] |Male[MESH] |Prospective Studies[MESH]Adiponectin to leptin ratio reflects inflammatory burden and survival (epmc).pdf DeepDyve Pubget Overpricing