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10.1016/j.cell.2021.07.025 http://scihub22266oqcxt.onion/10.1016/j.cell.2021.07.025 34332650!8299219!34332650     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2021 ; 184 (19): 4969-4980.e15 Nephropedia Template TP {{tp|p=34332650|t=2021. Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike |pdf=|usr=}}{{34332650}} gab.com Text Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=34332650 #FOAvip Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found seven major antibody competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of antibody-S complexes identified corresponding epitopic regions. Group assignment correlated with cross-CoV-reactivity breadth, neutralization potency, and convergent antibody signatures. Although emerging SARS-CoV-2 variants of concern escaped binding by many members of the groups associated with the most potent neutralizing activity, some antibodies in each of those groups retained affinity-suggesting that otherwise redundant components of a primary immune response are important for durable protection from evolving pathogens. Our results furnish a global atlas of S-specific memory B cell repertoires and illustrate properties driving viral escape and conferring robustness against emerging variants. Twit Text FOAVip Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=34332650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34332650 #FOAvip English Wikipedia <ref>{{Cite pmid|34332650}}</ref> Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike #MMPMID34332650 Tong P; Gautam A; Windsor IW; Travers M; Chen Y; Garcia N; Whiteman NB; McKay LGA; Storm N; Malsick LE; Honko AN; Lelis FJN; Habibi S; Jenni S; Cai Y; Rennick LJ; Duprex WP; McCarthy KR; Lavine CL; Zuo T; Lin J; Zuiani A; Feldman J; MacDonald EA; Hauser BM; Griffths A; Seaman MS; Schmidt AG; Chen B; Neuberg D; Bajic G; Harrison SC; Wesemann DR Cell 2021[Sep]; 184 (19): 4969-4980.e15 PMID34332650show ga Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to antigenically drifted variants. We charted memory B cell receptor-encoded antibodies from 19 COVID-19 convalescent subjects against SARS-CoV-2 spike (S) and found seven major antibody competition groups against epitopes recurrently targeted across individuals. Inclusion of published and newly determined structures of antibody-S complexes identified corresponding epitopic regions. Group assignment correlated with cross-CoV-reactivity breadth, neutralization potency, and convergent antibody signatures. Although emerging SARS-CoV-2 variants of concern escaped binding by many members of the groups associated with the most potent neutralizing activity, some antibodies in each of those groups retained affinity-suggesting that otherwise redundant components of a primary immune response are important for durable protection from evolving pathogens. Our results furnish a global atlas of S-specific memory B cell repertoires and illustrate properties driving viral escape and conferring robustness against emerging variants. äMemory B cell repertoire for recognition of evolving SARS-CoV-2 spike (epmc).pdf DeepDyve Pubget Overpricing