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10.1016/j.diabet.2021.101267

http://scihub22266oqcxt.onion/10.1016/j.diabet.2021.101267
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34332112!8317499!34332112
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suck abstract from ncbi


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pmid34332112      Diabetes+Metab 2021 ; 47 (6): 101267
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  • Diabetic ketoacidosis and mortality in COVID-19 infection #MMPMID34332112
  • Stevens JS; Bogun MM; McMahon DJ; Zucker J; Kurlansky P; Mohan S; Yin MT; Nickolas TL; Pajvani UB
  • Diabetes Metab 2021[Nov]; 47 (6): 101267 PMID34332112show ga
  • AIM: - Patients with diabetes have increased morbidity and mortality from COVID-19. Case reports describe patients with simultaneous COVID-19 and diabetic acidosis (DKA), however there is limited data on the prevalence, predictors and outcomes of DKA in these patients. METHODS: - Patients with COVID-19 were identified from the electronic medical record. DKA was defined by standardized criteria. Proportional hazard regression models were used to determine risk factors for, and mortality from DKA in COVID-19. RESULTS: - Of 2366 patients admitted for COVID-19, 157 (6.6%) patients developed DKA, 94% of whom had antecedent type 2 diabetes, 0.6% had antecedent type 1 diabetes, and 5.7% patients had no prior diagnosis of diabetes. Patients with DKA had increased hospital length of stay and in-patient mortality. Higher HbA1c predicted increased risk of incident DKA (HR 1.47 per 1% increase, 95% CI 1.40-1.54). Risk factors for mortality included older age (HR 1.07 per 5 years, 95% CI 1.06-1.08) and need for pressors (HR 2.33, 95% CI 1.82-2.98). Glucocorticoid use was protective in patients with and without DKA. CONCLUSION: - The combination of DKA and COVID-19 is associated with greater mortality, driven by older age and COVID-19 severity.
  • |*COVID-19/mortality[MESH]
  • |*Diabetic Ketoacidosis/epidemiology[MESH]
  • |Aged[MESH]


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