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10.1016/j.immuni.2021.07.007 http://scihub22266oqcxt.onion/10.1016/j.immuni.2021.07.007 34331874!ä!34331874 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunity 2021 ; 54 (8): 1883-1900.e5 Nephropedia Template TP {{tp|p=34331874|t=2021. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease |pdf=|usr=}}{{34331874}} gab.com Text Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease JO: Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34331874 #FOAvip Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly available tool to map MNPs and define conserved gene signatures of MNP populations. Next, we generated a MoMac-focused compendium that revealed an array of specialized cell subsets widely distributed across multiple tissues. Specific pathological forms were expanded in cancer and inflammation. All neoplastic tissues contained conserved tumor-associated macrophage populations. In particular, we focused on IL4I1(+)CD274(PD-L1)(+)IDO1(+) macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-gamma (IFN-gamma) and CD40/CD40L-induced maturation from IFN-primed monocytes. IL4I1_Macs exhibited immunosuppressive characteristics through tryptophan degradation and promoted the entry of regulatory T cell into tumors. This integrated analysis provides a robust online-available platform for uniform annotation and dissection of specific macrophage functions in healthy and pathological states. Twit Text FOAVip Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease ????Immunity http://www.kidney.de/pget.php?&tw=1&pmid=34331874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34331874 #FOAvip English Wikipedia <ref>{{Cite pmid|34331874}}</ref> Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease #MMPMID34331874 Mulder K; Patel AA; Kong WT; Piot C; Halitzki E; Dunsmore G; Khalilnezhad S; Irac SE; Dubuisson A; Chevrier M; Zhang XM; Tam JKC; Lim TKH; Wong RMM; Pai R; Khalil AIS; Chow PKH; Wu SZ; Al-Eryani G; Roden D; Swarbrick A; Chan JKY; Albani S; Derosa L; Zitvogel L; Sharma A; Chen J; Silvin A; Bertoletti A; Bleriot C; Dutertre CA; Ginhoux F Immunity 2021[Aug]; 54 (8): 1883-1900.e5 PMID34331874show ga Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a MNP single-cell RNA compendium (MNP-VERSE), a publicly available tool to map MNPs and define conserved gene signatures of MNP populations. Next, we generated a MoMac-focused compendium that revealed an array of specialized cell subsets widely distributed across multiple tissues. Specific pathological forms were expanded in cancer and inflammation. All neoplastic tissues contained conserved tumor-associated macrophage populations. In particular, we focused on IL4I1(+)CD274(PD-L1)(+)IDO1(+) macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-gamma (IFN-gamma) and CD40/CD40L-induced maturation from IFN-primed monocytes. IL4I1_Macs exhibited immunosuppressive characteristics through tryptophan degradation and promoted the entry of regulatory T cell into tumors. This integrated analysis provides a robust online-available platform for uniform annotation and dissection of specific macrophage functions in healthy and pathological states. |Arthritis, Rheumatoid/immunology[MESH] |COVID-19/immunology[MESH] |Dendritic Cells/*immunology[MESH] |Gene Expression Profiling[MESH] |Gene Expression/genetics/*immunology[MESH] |Humans[MESH] |Interferon-gamma/immunology[MESH] |L-Amino Acid Oxidase/metabolism[MESH] |Liver Cirrhosis/immunology[MESH] |Macrophages/immunology[MESH] |Monocytes/*immunology[MESH] |Neoplasms/immunology[MESH] |RNA, Small Cytoplasmic/genetics[MESH] |Single-Cell Analysis[MESH] |T-Lymphocytes, Regulatory/immunology[MESH] |Transcriptome/*genetics/immunology[MESH]Cross-tissue single-cell landscape of human monocytes and macrophages (epmc).pdf DeepDyve Pubget Overpricing