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10.1111/apa.16051

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34331326!8444808!34331326
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suck abstract from ncbi


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pmid34331326      Acta+Paediatr 2021 ; 110 (11): 3063-3068
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  • Multi-inflammatory syndrome and Kawasaki disease in children during the COVID-19 pandemic: A nationwide register-based study and time series analysis #MMPMID34331326
  • Koskela U; Helve O; Sarvikivi E; Helminen M; Nieminen T; Peltola V; Renko M; Saxen H; Pasma H; Pokka T; Honkila M; Tapiainen T
  • Acta Paediatr 2021[Nov]; 110 (11): 3063-3068 PMID34331326show ga
  • AIM: We investigated whether the ongoing COVID-19 pandemic was associated with the occurrence of Kawasaki disease or with multi-inflammatory syndrome in children (MIS-C). METHODS: This national Finnish register-based study was based on laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, MIS-C and Kawasaki disease cases. We performed a time series analysis on the occurrence of Kawasaki disease in 2016-2020. RESULTS: In 2020, there were 5170 laboratory-confirmed COVID-19 cases in children under 18 years of age and five fulfilled the MIS-C case definition. The occurrence of MIS-C was 0.97 per 1000 (95% confidence interval: 0.31-2.26) laboratory-confirmed SARS-CoV-2 infections in children. Our time series analysis showed that Kawasaki disease cases decreased during the COVID-19 pandemic. The seasonally adjusted incidence rate ratio was 0.49 (95% confidence interval: 0.32-0.74) when it was compared to pre-pandemic levels. This coincided with a reduced occurrence of respiratory infections, due to social distancing in the population. CONCLUSION: This nationwide register-based study found that MIS-C was a rare complication of the SARS-CoV-2 infection. The occurrence of Kawasaki disease and respiratory infections decreased during the pandemic. This suggests that transmissible microbes may play an important role in Kawasaki disease and social distancing may have a protective effect.
  • |*COVID-19/complications/epidemiology[MESH]
  • |*Mucocutaneous Lymph Node Syndrome/epidemiology[MESH]
  • |Adolescent[MESH]
  • |Child[MESH]
  • |Finland/epidemiology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]


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