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10.1016/j.clnesp.2021.05.004 http://scihub22266oqcxt.onion/10.1016/j.clnesp.2021.05.004 34330510!8149170!34330510     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34330510.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Nutr+ESPEN 2021 ; 44 (ä): 475-478 Nephropedia Template TP {{tp|p=34330510|t=2021. Gene signatures of autopsy lungs from obese patients with COVID-19 |pdf=|usr=}}{{34330510}} gab.com Text Gene signatures of autopsy lungs from obese patients with COVID-19 JO: Clin Nutr ESPEN http://www.kidney.de/pget.php?&tw=1&pmid=34330510 #FOAvip BACKGROUND & AIMS: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. METHODS: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. RESULTS: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. CONCLUSION: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. Twit Text FOAVip Gene signatures of autopsy lungs from obese patients with COVID-19 ????Clin Nutr ESPEN http://www.kidney.de/pget.php?&tw=1&pmid=34330510 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34330510 #FOAvip English Wikipedia <ref>{{Cite pmid|34330510}}</ref> Gene signatures of autopsy lungs from obese patients with COVID-19 #MMPMID34330510 Santos E Silva JC; Vasconcelos AP; Noma IHY; Noronha NY; Aquino R; Giddaluru J; Durao L; Costa-Martins AG; Schuch V; Moraes-Vieira PM; Nakaya HI Clin Nutr ESPEN 2021[Aug]; 44 (ä): 475-478 PMID34330510show ga BACKGROUND & AIMS: Obesity is associated with low grade systemic inflammation and insulin resistance. Although metabolic and immunological changes may contribute to the increased risk for COVID-19 mortality in obese, little is known about the impact of obesity in the lungs of patients with COVID-19. METHODS: We analyzed gene expression profiles of autopsy lungs of a cohort of 14 COVID-19 patients and 4 control individuals. Patients were divided into 3 groups according to their comorbidities: hypertension, type 2 diabetes (T2D) and obesity. We then identified the molecular alterations associated with these comorbidities in COVID-19 patients. RESULTS: Patients with only hypertension showed higher levels of inflammatory genes and B-cell related genes when compared to those with T2D and obesity. However, the levels of IFN-gamma, IL22, and CD274 (a ligand that binds to receptor PD1) were higher in COVID-19 patients with T2D and obesity. Several metabolic- and immune-associated genes such as G6PD, LCK and IL10 were significantly induced in the lungs of the obese group. CONCLUSION: Our findings suggest that SARS-CoV-2 infection in the lungs may exacerbate the immune response and chronic condition in obese COVID-19 patients. |Autopsy[MESH] |COVID-19/*complications/*genetics/immunology[MESH] |Cohort Studies[MESH] |Diabetes Mellitus, Type 2/complications/genetics/immunology[MESH] |Gene Expression/*genetics[MESH] |Humans[MESH] |Hypertension/complications/genetics/immunology[MESH] |Lung/*immunology[MESH] |Obesity/*complications/*genetics/immunology[MESH]Gene signatures of autopsy lungs from obese patients with COVID-19 (epmc).pdf DeepDyve Pubget Overpricing