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10.1111/ped.14938 http://scihub22266oqcxt.onion/10.1111/ped.14938 34329521!8447071!34329521     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34329521&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Pediatr+Int 2022 ; 64 (1): e14938 Nephropedia Template TP {{tp|p=34329521|t=2022. Inborn errors of metabolism and coronavirus disease 2019: Evaluation of the metabolic outcome |pdf=|usr=}}{{34329521}} gab.com Text Inborn errors of metabolism and coronavirus disease 2019: Evaluation of the metabolic outcome JO: Pediatr Int http://www.kidney.de/pget.php?&tw=1&pmid=34329521 #FOAvip BACKGROUND: Infectious diseases can result in a catabolic state and possibly trigger an acute metabolic decompensation in inborn errors of metabolism (IEM), which could be life threatening. Studies regarding the course of severe acute respiratory syndrome coronavirus 2 infections in patients with IEM are generally limited to case reports. Here, we aimed to evaluate the clinical findings of coronavirus disease 2019 (COVID-19) and describe the impact of severe acute respiratory syndrome coronavirus 2 infections on metabolic outcomes in IEM patients. METHODS: Patients who were diagnosed with different types of IEM and developed microbiologically confirmed COVID-19 infection were included. Clinical findings and laboratory results were recorded retrospectively in terms of both IEM and COVID-19. RESULTS: Eleven patients with diagnosis of intoxication type metabolic disorders, five patients with energy metabolism disorders, and six patients with complex molecular disorders were enrolled. The most frequent clinical finding was fever (52.1%) followed by fatigue/myalgia (47.8%). None of the patients was younger than 1 year. None of the patients presented severe or critical disease. In terms of metabolic decompensation, two patients diagnosed with propionic acidemia, one patient with methylmalonic acidemia and one patient with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency presented clinical and biochemical findings of an acute metabolic attack. CONCLUSIONS: Based on our results, IEM are not found to be an additional risk factor for severe COVID-19 infection. However, patients with intoxication type and energy metabolism disorders should be considered as a vulnerable population for COVID-19 and have a major risk of developing acute metabolic decompensation that can lead to life-threatening complications. Twit Text FOAVip Inborn errors of metabolism and coronavirus disease 2019: Evaluation of the metabolic outcome ????Pediatr Int http://www.kidney.de/pget.php?&tw=1&pmid=34329521 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34329521 #FOAvip English Wikipedia <ref>{{Cite pmid|34329521}}</ref> Inborn errors of metabolism and coronavirus disease 2019: Evaluation of the metabolic outcome #MMPMID34329521 Zubarioglu T; Hopurcuoglu D; Ahmadzada S; Uzunyayla-Inci G; Cansever MS; Kiykim E; Aktuglu-Zeybek C Pediatr Int 2022[Jan]; 64 (1): e14938 PMID34329521show ga BACKGROUND: Infectious diseases can result in a catabolic state and possibly trigger an acute metabolic decompensation in inborn errors of metabolism (IEM), which could be life threatening. Studies regarding the course of severe acute respiratory syndrome coronavirus 2 infections in patients with IEM are generally limited to case reports. Here, we aimed to evaluate the clinical findings of coronavirus disease 2019 (COVID-19) and describe the impact of severe acute respiratory syndrome coronavirus 2 infections on metabolic outcomes in IEM patients. METHODS: Patients who were diagnosed with different types of IEM and developed microbiologically confirmed COVID-19 infection were included. Clinical findings and laboratory results were recorded retrospectively in terms of both IEM and COVID-19. RESULTS: Eleven patients with diagnosis of intoxication type metabolic disorders, five patients with energy metabolism disorders, and six patients with complex molecular disorders were enrolled. The most frequent clinical finding was fever (52.1%) followed by fatigue/myalgia (47.8%). None of the patients was younger than 1 year. None of the patients presented severe or critical disease. In terms of metabolic decompensation, two patients diagnosed with propionic acidemia, one patient with methylmalonic acidemia and one patient with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency presented clinical and biochemical findings of an acute metabolic attack. CONCLUSIONS: Based on our results, IEM are not found to be an additional risk factor for severe COVID-19 infection. However, patients with intoxication type and energy metabolism disorders should be considered as a vulnerable population for COVID-19 and have a major risk of developing acute metabolic decompensation that can lead to life-threatening complications. |*Amino Acid Metabolism, Inborn Errors[MESH] |*COVID-19[MESH] |*Metabolism, Inborn Errors/complications/diagnosis/epidemiology[MESH] |*Propionic Acidemia/complications[MESH] |Humans[MESH] |Retrospective Studies[MESH]Inborn errors of metabolism and coronavirus disease 2019: Evaluation o(epmc).pdf DeepDyve Pubget Overpricing