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10.1111/bcp.15013 http://scihub22266oqcxt.onion/10.1111/bcp.15013 34327732!8444885!34327732     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Clin+Pharmacol 2022 ; 88 (3): 1054-1062 Nephropedia Template TP {{tp|p=34327732|t=2022. Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial |pdf=|usr=}}{{34327732}} gab.com Text Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial JO: Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34327732 #FOAvip AIMS: Hydroxychloroquine has been suggested as possible treatment for severe acute respiratory syndrome-coronavirus-2. Studies reported an increased risk of QTcF-prolongation after treatment with hydroxychloroquine. The aim of this study was to analyse the concentration-dependent effects of hydroxychloroquine on the ventricular repolarization, including QTcF-duration and T-wave morphology. METHODS: Twenty young (</=30 y) and 20 elderly (65-75 y) healthy male subjects were included. Subjects were randomized to receive either a total dose of 2400 mg hydroxychloroquine over 5 days, or placebo (ratio 1:1). Follow-up duration was 28 days. Electrocardiograms (ECGs) were recorded as triplicate at baseline and 4 postdose single recordings, followed by hydroxychloroquine concentration measurements. ECG intervals (RR, QRS, PR, QTcF, J-Tpc, Tp-Te) and T-wave morphology, measured with the morphology combination score, were analysed with a prespecified linear mixed effects concentration-effect model. RESULTS: There were no significant associations between hydroxychloroquine concentrations and ECG characteristics, including RR-, QRS- and QTcF-interval (P = .09, .34, .25). Mean DeltaDeltaQTcF-interval prolongation did not exceed 5 ms and the upper limit of the 90% confidence interval did not exceed 10 ms at the highest measured concentrations (200 ng/mL). There were no associations between hydroxychloroquine concentration and the T-wave morphology (P = .34 for morphology combination score). There was no significant effect of age group on ECG characteristics. CONCLUSION: In this study, hydroxychloroquine did not affect ventricular repolarization, including the QTcF-interval and T-wave morphology, at plasma concentrations up to 200 ng/mL. Based on this analysis, hydroxychloroquine does not appear to increase the risk of QTcF-induced arrhythmias. Twit Text FOAVip Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial ????Br J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=34327732 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34327732 #FOAvip English Wikipedia <ref>{{Cite pmid|34327732}}</ref> Effect of hydroxychloroquine on the cardiac ventricular repolarization: A randomized clinical trial #MMPMID34327732 Eveleens Maarse BC; Graff C; Kanters JK; van Esdonk MJ; Kemme MJB; In 't Veld AE; Jansen MAA; Moerland M; Gal P Br J Clin Pharmacol 2022[Mar]; 88 (3): 1054-1062 PMID34327732show ga AIMS: Hydroxychloroquine has been suggested as possible treatment for severe acute respiratory syndrome-coronavirus-2. Studies reported an increased risk of QTcF-prolongation after treatment with hydroxychloroquine. The aim of this study was to analyse the concentration-dependent effects of hydroxychloroquine on the ventricular repolarization, including QTcF-duration and T-wave morphology. METHODS: Twenty young ( |*COVID-19 Drug Treatment[MESH] |*Long QT Syndrome/chemically induced[MESH] |Aged[MESH] |Electrocardiography[MESH] |Heart Rate[MESH] |Humans[MESH] |Hydroxychloroquine/adverse effects[MESH] |Male[MESH]Effect of hydroxychloroquine on the cardiac ventricular repolarization(epmc).pdf DeepDyve Pubget Overpricing