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10.3389/fimmu.2021.693054 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.693054 34326844!8315546!34326844     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 693054 Nephropedia Template TP {{tp|p=34326844|t=2021. Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects |pdf=|usr=}}{{34326844}} gab.com Text Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34326844 #FOAvip Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8(+) T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8(+) T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8(+) T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8(+) T-cell responses. Twit Text FOAVip Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34326844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326844 #FOAvip English Wikipedia <ref>{{Cite pmid|34326844}}</ref> Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older Subjects #MMPMID34326844 Gallerani E; Proietto D; Dallan B; Campagnaro M; Pacifico S; Albanese V; Marzola E; Marconi P; Caputo A; Appay V; Gavioli R; Nicoli F Front Immunol 2021[]; 12 (ä): 693054 PMID34326844show ga Advanced age is associated with severe symptoms and death upon SARS-CoV-2 infection. Virus-specific CD8(+) T-cell responses have shown to be protective toward critical COVID-19 manifestations, suggesting that suboptimal cellular immunity may contribute to the age-pattern of the disease. The induction of a CD8(+) T-cell response against an emerging pathogen like SARS-CoV-2 relies on the activation of naive T cells. To investigate whether the primary CD8(+) T-cell response against this virus is defective in advanced age, we used an in vitro approach to prime SARS-CoV-2-specific naive CD8(+) T cells from healthy, unexposed donors of different age groups. Compared to younger adults, older individuals display a poor SARS-CoV-2-specific T-cell priming capacity in terms of both magnitude and quality of the response. In addition, older subjects recognize a lower number of epitopes. Our results implicate that immune aging is associated with altered primary SARS-CoV-2-specific CD8(+) T-cell responses. |Adult[MESH] |Aged[MESH] |Aging/*immunology[MESH] |Antigens, Viral/immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology[MESH] |Cells, Cultured[MESH] |Enzyme-Linked Immunospot Assay[MESH] |Epitopes, T-Lymphocyte/immunology[MESH] |Gene Expression Regulation[MESH] |Healthy Volunteers[MESH] |Humans[MESH] |Interferon-gamma/genetics/metabolism[MESH] |Lymphocyte Activation[MESH] |Middle Aged[MESH] |Peptides/immunology[MESH] |SARS-CoV-2/*immunology[MESH]Impaired Priming of SARS-CoV-2-Specific Naive CD8(+) T Cells in Older (epmc).pdf DeepDyve Pubget Overpricing