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10.3389/fimmu.2021.690477 http://scihub22266oqcxt.onion/10.3389/fimmu.2021.690477 34326843!8313986!34326843     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2021 ; 12 (ä): 690477 Nephropedia Template TP {{tp|p=34326843|t=2021. The Many Faces of JAKs and STATs Within the COVID-19 Storm |pdf=|usr=}}{{34326843}} gab.com Text The Many Faces of JAKs and STATs Within the COVID-19 Storm JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34326843 #FOAvip The positive-sense single stranded RNA virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), resulted in a global pandemic with horrendous health and economic consequences not seen in a century. At a finer scale, immunologically, many of these devastating effects by SARS-CoV-2 can be traced to a "cytokine storm" resulting in the simultaneous activation of Janus Kinases (JAKs) and Signal Transducers and Activators of Transcription (STAT) proteins downstream of the many cytokine receptor families triggered by elevated cytokines found in Coronavirus Disease 2019 (COVID-19). In this report, cytokines found in the storm are discussed in relation to the JAK-STAT pathway in response to SARS-CoV-2 and the lessons learned from RNA viruses and previous Coronaviruses (CoVs). Therapeutic strategies to counteract the SARS-CoV-2 mediated storm are discussed with an emphasis on cell signaling and JAK inhibition. Twit Text FOAVip The Many Faces of JAKs and STATs Within the COVID-19 Storm ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=34326843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326843 #FOAvip English Wikipedia <ref>{{Cite pmid|34326843}}</ref> The Many Faces of JAKs and STATs Within the COVID-19 Storm #MMPMID34326843 Grant AH; Estrada A 3rd; Ayala-Marin YM; Alvidrez-Camacho AY; Rodriguez G; Robles-Escajeda E; Cadena-Medina DA; Rodriguez AC; Kirken RA Front Immunol 2021[]; 12 (ä): 690477 PMID34326843show ga The positive-sense single stranded RNA virus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), resulted in a global pandemic with horrendous health and economic consequences not seen in a century. At a finer scale, immunologically, many of these devastating effects by SARS-CoV-2 can be traced to a "cytokine storm" resulting in the simultaneous activation of Janus Kinases (JAKs) and Signal Transducers and Activators of Transcription (STAT) proteins downstream of the many cytokine receptor families triggered by elevated cytokines found in Coronavirus Disease 2019 (COVID-19). In this report, cytokines found in the storm are discussed in relation to the JAK-STAT pathway in response to SARS-CoV-2 and the lessons learned from RNA viruses and previous Coronaviruses (CoVs). Therapeutic strategies to counteract the SARS-CoV-2 mediated storm are discussed with an emphasis on cell signaling and JAK inhibition. |Animals[MESH] |COVID-19/*immunology[MESH] |Cytokine Release Syndrome/*immunology[MESH] |Cytokines/metabolism[MESH] |Humans[MESH] |Janus Kinases/metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |STAT Transcription Factors/metabolism[MESH]The Many Faces of JAKs and STATs Within the COVID-19 Storm (epmc).pdf DeepDyve Pubget Overpricing