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10.1038/s42003-021-02453-y http://scihub22266oqcxt.onion/10.1038/s42003-021-02453-y 34326460!8322398!34326460     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2021 ; 4 (1): 926 Nephropedia Template TP {{tp|p=34326460|t=2021. Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection |pdf=|usr=}}{{34326460}} gab.com Text Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34326460 #FOAvip Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a SARS-CoV-2 spike-pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection in a clinically relevant stem cell-derived cardiomyocyte line. Discovery of new medicines will be critical for protecting the heart in patients with SARS-CoV-2, and for individuals where vaccination is contraindicated. Twit Text FOAVip Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=34326460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326460 #FOAvip English Wikipedia <ref>{{Cite pmid|34326460}}</ref> Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection #MMPMID34326460 Williams TL; Colzani MT; Macrae RGC; Robinson EL; Bloor S; Greenwood EJD; Zhan JR; Strachan G; Kuc RE; Nyimanu D; Maguire JJ; Lehner PJ; Sinha S; Davenport AP Commun Biol 2021[Jul]; 4 (1): 926 PMID34326460show ga Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a SARS-CoV-2 spike-pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection in a clinically relevant stem cell-derived cardiomyocyte line. Discovery of new medicines will be critical for protecting the heart in patients with SARS-CoV-2, and for individuals where vaccination is contraindicated. |Antiviral Agents/*pharmacology[MESH] |Benztropine/pharmacology[MESH] |Drug Evaluation, Preclinical/*methods[MESH] |Human Embryonic Stem Cells/*cytology[MESH] |Humans[MESH] |Myocytes, Cardiac/cytology/*drug effects/*virology[MESH] |Peptides/pharmacology[MESH]Human embryonic stem cell-derived cardiomyocyte platform screens inhib(epmc).pdf DeepDyve Pubget Overpricing