Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-021-24938-4 http://scihub22266oqcxt.onion/10.1038/s41467-021-24938-4 34326343!8322064!34326343     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4678 Nephropedia Template TP {{tp|p=34326343|t=2021. SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection |pdf=|usr=}}{{34326343}} gab.com Text SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34326343 #FOAvip SARS-CoV-2 infection of children leads to a mild illness and the immunological differences with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4(+) T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8(+) T cell responses increase with time post-infection. Infected children have lower CD4(+) and CD8(+) T cell responses to SARS-CoV-2 structural and ORF1ab proteins when compared with infected adults, comparable T cell polyfunctionality and reduced CD4(+) T cell effector memory. Compared with adults, children have lower levels of antibodies to beta-coronaviruses, indicating differing baseline immunity. Total T follicular helper responses are increased, whilst monocyte numbers are reduced, indicating rapid adaptive co-ordination of the T and B cell responses and differing levels of inflammation. Therefore, reduced prior beta-coronavirus immunity and reduced T cell activation in children might drive milder COVID-19 pathogenesis. Twit Text FOAVip SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34326343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326343 #FOAvip English Wikipedia <ref>{{Cite pmid|34326343}}</ref> SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infection #MMPMID34326343 Cohen CA; Li APY; Hachim A; Hui DSC; Kwan MYW; Tsang OTY; Chiu SS; Chan WH; Yau YS; Kavian N; Ma FNL; Lau EHY; Cheng SMS; Poon LLM; Peiris M; Valkenburg SA Nat Commun 2021[Jul]; 12 (1): 4678 PMID34326343show ga SARS-CoV-2 infection of children leads to a mild illness and the immunological differences with adults are unclear. Here, we report SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4(+) T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8(+) T cell responses increase with time post-infection. Infected children have lower CD4(+) and CD8(+) T cell responses to SARS-CoV-2 structural and ORF1ab proteins when compared with infected adults, comparable T cell polyfunctionality and reduced CD4(+) T cell effector memory. Compared with adults, children have lower levels of antibodies to beta-coronaviruses, indicating differing baseline immunity. Total T follicular helper responses are increased, whilst monocyte numbers are reduced, indicating rapid adaptive co-ordination of the T and B cell responses and differing levels of inflammation. Therefore, reduced prior beta-coronavirus immunity and reduced T cell activation in children might drive milder COVID-19 pathogenesis. |Adolescent[MESH] |Adult[MESH] |Age Factors[MESH] |Aged[MESH] |Antibodies, Viral/immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |COVID-19/*immunology/metabolism/pathology/virology[MESH] |Child[MESH] |Child, Preschool[MESH] |Female[MESH] |Humans[MESH] |Infant[MESH] |Inflammation/immunology[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology/isolation & purification/metabolism[MESH]SARS-CoV-2 specific T cell responses are lower in children and increas(epmc).pdf DeepDyve Pubget Overpricing