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10.1038/s41467-021-24579-7 http://scihub22266oqcxt.onion/10.1038/s41467-021-24579-7 34326317!8322137!34326317     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34326317&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 4617 Nephropedia Template TP {{tp|p=34326317|t=2021. Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers |pdf=|usr=}}{{34326317}} gab.com Text Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34326317 #FOAvip Several COVID-19 vaccines have received emergency approval. Here we assess the immunogenicity of a single dose of the AZD1222 vaccine, at one month, in a cohort of health care workers (HCWs) (629 naive and 26 previously infected). 93.4% of naive HCWs seroconverted, irrespective of age and gender. Haemagglutination test for antibodies to the receptor binding domain (RBD), surrogate neutralization assay (sVNT) and ex vivo IFNgamma ELISpot assays were carried out in a sub-cohort. ACE2 blocking antibodies (measured by sVNT) were detected in 67/69 (97.1%) of naive HCWs. Antibody levels to the RBD of the wild-type virus were higher than to RBD of B.1.1.7, and titres to B.1.351 were very low. Ex vivo T cell responses were observed in 30.8% to 61.7% in naive HCWs. Previously infected HCWs, developed significantly higher (p < 0.0001) ACE2 blocking antibodies and antibodies to the RBD for the variants B.1.1.7 and B.1.351. This study shows high seroconversion after one vaccine dose, but also suggests that one vaccine dose may be insufficient to protect against emerging variants. Twit Text FOAVip Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=34326317 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326317 #FOAvip English Wikipedia <ref>{{Cite pmid|34326317}}</ref> Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers #MMPMID34326317 Jeewandara C; Kamaladasa A; Pushpakumara PD; Jayathilaka D; Aberathna IS; Danasekara DRSR; Guruge D; Ranasinghe T; Dayarathna S; Pathmanathan T; Somathilake G; Deshan Madhusanka PA; Ramu ST; Pramanayagam Jayadas TT; Kuruppu H; Wijesinghe A; Thashmi Nimasha HM; Milroy D; Nandasena AA; Nilanka Sanjeewani PKG; Wijayamuni R; Samaraweera S; Schimanski L; Tan TK; Dong T; Ogg GS; Townsend A; Malavige GN Nat Commun 2021[Jul]; 12 (1): 4617 PMID34326317show ga Several COVID-19 vaccines have received emergency approval. Here we assess the immunogenicity of a single dose of the AZD1222 vaccine, at one month, in a cohort of health care workers (HCWs) (629 naive and 26 previously infected). 93.4% of naive HCWs seroconverted, irrespective of age and gender. Haemagglutination test for antibodies to the receptor binding domain (RBD), surrogate neutralization assay (sVNT) and ex vivo IFNgamma ELISpot assays were carried out in a sub-cohort. ACE2 blocking antibodies (measured by sVNT) were detected in 67/69 (97.1%) of naive HCWs. Antibody levels to the RBD of the wild-type virus were higher than to RBD of B.1.1.7, and titres to B.1.351 were very low. Ex vivo T cell responses were observed in 30.8% to 61.7% in naive HCWs. Previously infected HCWs, developed significantly higher (p < 0.0001) ACE2 blocking antibodies and antibodies to the RBD for the variants B.1.1.7 and B.1.351. This study shows high seroconversion after one vaccine dose, but also suggests that one vaccine dose may be insufficient to protect against emerging variants. |Adult[MESH] |Antibodies, Neutralizing/biosynthesis/*immunology[MESH] |COVID-19 Vaccines/*therapeutic use[MESH] |COVID-19/*immunology/prevention & control/virology[MESH] |ChAdOx1 nCoV-19[MESH] |Dose-Response Relationship, Immunologic[MESH] |Female[MESH] |Health Personnel[MESH] |Humans[MESH] |Immunity[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology/isolation & purification[MESH]Immune responses to a single dose of the AZD1222/Covishield vaccine in(epmc).pdf DeepDyve Pubget Overpricing