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10.1126/science.abi4708 http://scihub22266oqcxt.onion/10.1126/science.abi4708 34326236!8501941!34326236     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2021 ; 373 (6554): 541-547 Nephropedia Template TP {{tp|p=34326236|t=2021. Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 |pdf=|usr=}}{{34326236}} gab.com Text Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=34326236 #FOAvip Repurposing drugs as treatments for COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with sigma receptor ligands and expanding to other drugs from screening in the field, we became concerned that phospholipidosis was a shared mechanism underlying the antiviral activity of many repurposed drugs. For all of the 23 cationic amphiphilic drugs we tested, including hydroxychloroquine, azithromycin, amiodarone, and four others already in clinical trials, phospholipidosis was monotonically correlated with antiviral efficacy. Conversely, drugs active against the same targets that did not induce phospholipidosis were not antiviral. Phospholipidosis depends on the physicochemical properties of drugs and does not reflect specific target-based activities-rather, it may be considered a toxic confound in early drug discovery. Early detection of phospholipidosis could eliminate these artifacts, enabling a focus on molecules with therapeutic potential. Twit Text FOAVip Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 ????Science http://www.kidney.de/pget.php?&tw=1&pmid=34326236 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34326236 #FOAvip English Wikipedia <ref>{{Cite pmid|34326236}}</ref> Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 #MMPMID34326236 Tummino TA; Rezelj VV; Fischer B; Fischer A; O'Meara MJ; Monel B; Vallet T; White KM; Zhang Z; Alon A; Schadt H; O'Donnell HR; Lyu J; Rosales R; McGovern BL; Rathnasinghe R; Jangra S; Schotsaert M; Galarneau JR; Krogan NJ; Urban L; Shokat KM; Kruse AC; Garcia-Sastre A; Schwartz O; Moretti F; Vignuzzi M; Pognan F; Shoichet BK Science 2021[Jul]; 373 (6554): 541-547 PMID34326236show ga Repurposing drugs as treatments for COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning with sigma receptor ligands and expanding to other drugs from screening in the field, we became concerned that phospholipidosis was a shared mechanism underlying the antiviral activity of many repurposed drugs. For all of the 23 cationic amphiphilic drugs we tested, including hydroxychloroquine, azithromycin, amiodarone, and four others already in clinical trials, phospholipidosis was monotonically correlated with antiviral efficacy. Conversely, drugs active against the same targets that did not induce phospholipidosis were not antiviral. Phospholipidosis depends on the physicochemical properties of drugs and does not reflect specific target-based activities-rather, it may be considered a toxic confound in early drug discovery. Early detection of phospholipidosis could eliminate these artifacts, enabling a focus on molecules with therapeutic potential. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |A549 Cells[MESH] |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology/therapeutic use/toxicity[MESH] |COVID-19/virology[MESH] |Cations[MESH] |Chlorocebus aethiops[MESH] |Dose-Response Relationship, Drug[MESH] |Female[MESH] |Humans[MESH] |Lipidoses/*chemically induced[MESH] |Mice[MESH] |Microbial Sensitivity Tests[MESH] |Phospholipids/*metabolism[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Surface-Active Agents/chemistry/pharmacology/toxicity[MESH] |Vero Cells[MESH]Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-(epmc).pdf DeepDyve Pubget Overpricing